ArticleGenetics2004
Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
- In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development inInternational journal of molecular sciences · 2021Article
- Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 inG3 (Bethesda, Md.) · 2019Article
- A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism.BMC genetics · 2019Article
- Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.Molecular biology of the cell · 2013Article
- Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2.Genetics · 2010Article
- Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Review
- Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.Chromosoma · 2008Article
- Orchestration of chromatin-based processes: mind the TRRAP.Oncogene · 2007Review
- High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster.Genetics · 2007Article
- Update of the Anopheles gambiae PEST genome assembly.Genome biology · 2007Article
- Euchromatin and pericentromeric heterochromatin: comparative composition in the tomato genome.Genetics · 2006Article
- Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.Molecular and cellular biology · 2006Article
- Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.Genome biology · 2006Article
- Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals.Genome research · 2005Article
- A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.Genetics · 2005Article
- Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster.Genetics · 2005Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behind. We describe a combined genetic and bioinformatics approach to the base of the right arm of the Drosophila melanogaster second chromosome, at the boundary between pericentric heterochromatin and euchromatin. We used resources provided by the genome project to derive a physical map of the region, examine gene density, and estimate the number of potential genes. We also carried out a large-scale genetic screen for lethal mutations in the region. We identified new alleles of the known essential genes and also identified mutations in 21 novel loci. Fourteen complementation groups map proximal to the assembled sequence. We used PCR to map the endpoints of several deficiencies and used the same set of deficiencies to order the essential genes, correlating the genetic and physical map. This allowed us to assign two of the complementation groups to particular "computed/curated genes" (CGs), one of which is Nipped-A, which our evidence suggests encodes Drosophila Tra1/TRRAP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.