ArticleGenetics2004
Controlling the proportion of false positives in multiple dependent tests.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- Trial
- Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.Molecular psychiatry · 2011Trial
- Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.Molecular psychiatry · 2011Trial
- Genomewide association for schizophrenia in the CATIE study: results of stage 1.Molecular psychiatry · 2008Trial
- Pharmacogenetic study of antipsychotic-induced lipid and BMI changes in Chinese schizophrenia patients: A Genome-Wide Association Study.Translational psychiatry · 2025Article
- Transcriptome Analysis of DAMP-Induced Root Growth Regulation and Defense in Foxtail Millet.International journal of molecular sciences · 2025Article
- Transcriptome analysis and identification of the low potassium stress-responsive gene SiSnRK2.6 in foxtail millet (Setaria italica L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Population size in QTL detection using quantile regression in genome-wide association studies.Scientific reports · 2023Article
- Application of Bayesian genomic prediction methods to genome-wide association analyses.Genetics, selection, evolution : GSE · 2022Review
- Suitability of GWAS as a Tool to Discover SNPs Associated with Tick Resistance in Cattle: A Review.Pathogens (Basel, Switzerland) · 2021Review
- Emerging issues in genomic selection.Journal of animal science · 2021Article
- Expression Levels of Three Key Genes CCNB1, CDC20, and CENPF in HCC Are Associated With Antitumor Immunity.Frontiers in oncology · 2021Article
- MultipleTesting.com: A tool for life science researchers for multiple hypothesis testing correction.PloS one · 2021Article
- Higher visit-to-visit total cholesterol variability is associated with lower cognitive function among middle-aged and elderly Chinese men.Scientific reports · 2020Article
- Article
- Genome-Wide Association Study in Mexican Holstein Cattle Reveals Novel Quantitative Trait Loci Regions and Confirms Mapped Loci for Resistance to Bovine Tuberculosis.Animals : an open access journal from MDPI · 2019Article
- Signatures of negative selection in the genetic architecture of human complex traits.Nature genetics · 2018Article
- Inference on the Genetic Basis of Eye and Skin Color in an Admixed Population via Bayesian Linear Mixed Models.Genetics · 2017Article
- Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.Annals of neurology · 2016Article
- IL-22 regulation of functional gene expression in salivary gland cells.Genomics data · 2016Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome scan mapping experiments involve multiple tests of significance. Thus, controlling the error rate in such experiments is important. Simple extension of classical concepts results in attempts to control the genomewise error rate (GWER), i.e., the probability of even a single false positive among all tests. This results in very stringent comparisonwise error rates (CWER) and, consequently, low experimental power. We here present an approach based on controlling the proportion of false positives (PFP) among all positive test results. The CWER needed to attain a desired PFP level does not depend on the correlation among the tests or on the number of tests as in other approaches. To estimate the PFP it is necessary to estimate the proportion of true null hypotheses. Here we show how this can be estimated directly from experimental results. The PFP approach is similar to the false discovery rate (FDR) and positive false discovery rate (pFDR) approaches. For a fixed CWER, we have estimated PFP, FDR, pFDR, and GWER through simulation under a variety of models to illustrate practical and philosophical similarities and differences among the methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.