ArticleGenetics2004
Influence of dominance, leptokurtosis and pleiotropy of deleterious mutations on quantitative genetic variation at mutation-selection balance.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow.Genetics · 2024Article
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- Selection in males purges the mutation load on female fitness.Evolution letters · 2021Article
- Sexually antagonistic selection promotes genetic divergence between males and females in an ant.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sex-specific dominance reversal of genetic variation for fitness.PLoS biology · 2018Article
- The effects of stochastic and episodic movement of the optimum on the evolution of the G-matrix and the response of the trait mean to selection.Journal of evolutionary biology · 2012Article
- Mutations and quantitative genetic variation: lessons from Drosophila.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
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- Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms.American journal of human genetics · 2008Article
- Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.American journal of human genetics · 2007Article
- Systems-level analysis and evolution of the phototransduction network in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Gene action of new mutations in Arabidopsis thaliana.Genetics · 2006Article
- The effect of antagonistic pleiotropy on the estimation of the average coefficient of dominance of deleterious mutations.Genetics · 2005Article
- Theoretical models of selection and mutation on quantitative traits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Predictions of patterns of response to artificial selection in lines derived from natural populations.Genetics · 2005Article
- Analysis of the estimators of the average coefficient of dominance of deleterious mutations.Genetics · 2004Article
- Redistribution of gene frequency and changes of genetic variation following a bottleneck in population size.Genetics · 2004Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
In models of maintenance of genetic variance (V (G)) it has often been assumed that mutant alleles act additively. However, experimental data show that the dominance coefficient varies among mutant alleles and those of large effect tend to be recessive. On the basis of empirical knowledge of mutations, a joint-effect model of pleiotropic and real stabilizing selection that includes dominance is constructed and analyzed. It is shown that dominance can dramatically alter the prediction of equilibrium V (G). Analysis indicates that for the situations where mutations are more recessive for fitness than for a quantitative trait, as supported by the available data, the joint-effect model predicts a significantly higher V (G) than does an additive model. Importantly, for what seem to be realistic distributions of mutational effects (i.e., many mutants may not affect the quantitative trait substantially but are likely to affect fitness), the observed high levels of genetic variation in the quantitative trait under strong apparent stabilizing selection can be generated. This investigation supports the hypothesis that most V (G) comes from the alleles nearly neutral for fitness in heterozygotes while apparent stabilizing selection is contributed mainly by the alleles of large effect on the quantitative trait. Thus considerations of dominance coefficients of mutations lend further support to our previous conclusion that mutation-selection balance is a plausible mechanism of the maintenance of the genetic variance in natural populations.
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