ArticleGenetics2004
Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
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- Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.Genome biology · 2020Article
- Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- Discovery of an Experimental Model of Unicuspid Aortic Valve.Journal of the American Heart Association · 2018Article
- Role of EGF receptor signaling on morphogenesis of eyelid and meibomian glands.Experimental eye research · 2017Review
- An ENU-induced splice site mutation of mouse Col1a1 causing recessive osteogenesis imperfecta and revealing a novel splicing rescue.Scientific reports · 2017Article
- Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.Annual review of physiology · 2017Review
- Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.Developmental biology · 2016Article
- IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- NHE8 is essential for RPE cell polarity and photoreceptor survival.Scientific reports · 2015Article
- Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development.The Journal of biological chemistry · 2013Article
- EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers.International journal of molecular sciences · 2013Review
- ADAM17 transactivates EGFR signaling during embryonic eyelid closure.Investigative ophthalmology & visual science · 2013Article
- Dissecting immunity by germline mutagenesis.Immunology · 2012Review
- Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.Carcinogenesis · 2012Article
- Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene.BMC genetics · 2012Article
- A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
In the course of a large-scale program of ENU mutagenesis, we isolated a dominant mutation, called Velvet. The mutation was found to be uniformly lethal to homozygotes, which do not survive E13.5. Mice heterozygous for the Velvet mutation are born with eyelids open and demonstrate a wavy coat and curly vibrissae. The mutation was mapped to the proximal end of chromosome 11 by genome-wide linkage analysis. On 249 meioses, the locus was confined to a 2.7-Mb region, which included the epidermal growth factor receptor gene (Egfr). An A --> G transition in the Egfr coding region of Velvet mice was identified, causing the amino acid substitution D833G. This substitution alters an essential triad of amino acids (DFG --> GFG) that is normally required for coordination of the ATP substrate. As such, kinase activity is at least mostly abolished, but quaternary structure of the receptor is presumably maintained, accounting for the dominant effect. Velvet is the first known dominant representative of the Egfr allelic series that is fully viable, a fact that makes it particularly useful for developmental studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.