ArticleGenetics2004
The Podospora rmp1 gene implicated in nucleus-mitochondria cross-talk encodes an essential protein whose subcellular location is developmentally regulated.
Article in Genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Mutations inJournal of fungi (Basel, Switzerland) · 2024Article
- A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence inJournal of fungi (Basel, Switzerland) · 2021Review
- Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes.The New phytologist · 2021Review
- Editorial: Yeast Differentiation: From Cell-to-Cell Heterogeneity to Replicative Aging and Regulated Cell Death.Frontiers in cell and developmental biology · 2021Article
- Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension.Frontiers in cell and developmental biology · 2021Article
- Maintaining two mating types: structure of the mating type locus and its role in heterokaryosis in Podospora anserina.Genetics · 2014Article
- Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain.PloS one · 2012Article
- Article
- Roles of Oxa1-related inner-membrane translocases in assembly of respiratory chain complexes.Biochimica et biophysica acta · 2009Review
- The novel ER membrane protein PRO41 is essential for sexual development in the filamentous fungus Sordaria macrospora.Molecular microbiology · 2007Article
- A two-step protocol for efficient deletion of genes in the filamentous ascomycete Podospora anserina.Current genetics · 2005Article
- Interaction between the oxa1 and rmp1 genes modulates respiratory complex assembly and life span in Podospora anserina.Genetics · 2005Article
- Maintaining heterokaryosis in pseudo-homothallic fungi.Communicative & integrative biologyArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been previously reported that, at the time of death, the Podospora anserina AS1-4 mutant strains accumulate specific deleted forms of the mitochondrial genome and that their life spans depend on two natural alleles (variants) of the rmp1 gene: AS1-4 rmp1-2 strains exhibit life spans strikingly longer than those of AS1-4 rmp1-1. Here, we show that rmp1 is an essential gene. In silico analyses of eight rmp1 natural alleles present in Podospora isolates and of the putative homologs of this orphan gene in other filamentous fungi suggest that rmp1 evolves rapidly. The RMP1 protein is localized in the mitochondrial and/or the cytosolic compartment, depending on cell type and developmental stage. Strains producing RMP1 without its mitochondrial targeting peptide are viable but exhibit vegetative and sexual defects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.