ReviewCurrent opinion in neurobiology2004
Retinal axon guidance: novel mechanisms for steering.
Review in Current opinion in neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Delta family protocadherins contribute to protoglomerular targeting of olfactory sensory neuron axons in the olfactory bulb.PLoS genetics · 2026Article
- Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.IEEE transactions on medical imaging · 2024Article
- Development and Degeneration of Retinal Ganglion Cell Axons inMolecules and cells · 2022Article
- Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting.Neural development · 2022Article
- Manipulation of Axonal Outgrowth via Exogenous Low Forces.International journal of molecular sciences · 2020Review
- Extremely Low Forces Induce Extreme Axon Growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead.International journal of molecular sciences · 2020Review
- Plasticity-related gene 3 promotes neurite shaft protrusion.BMC neuroscience · 2013Article
- Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction.The Journal of biological chemistry · 2011Article
- Second messengers and membrane trafficking direct and organize growth cone steering.Nature reviews. Neuroscience · 2011Review
- Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The role of local protein synthesis and degradation in axon regeneration.Experimental neurology · 2010Review
- The trip of the tip: understanding the growth cone machinery.Nature reviews. Molecular cell biology · 2009Review
- Identification of a developmentally regulated pathway of membrane retrieval in neuronal growth cones.Journal of cell science · 2008Article
- Function and regulation of local axonal translation.Current opinion in neurobiology · 2008Review
- Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation.Development (Cambridge, England) · 2007Article
- Rho GTPases regulate PTPmu-mediated nasal neurite outgrowth and temporal repulsion of retinal ganglion cell neurons.Molecular and cellular neurosciences · 2007Article
- RanBPM contributes to Semaphorin3A signaling through plexin-A receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- EphB3: an endogenous mediator of adult axonal plasticity and regrowth after CNS injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Central and peripheral axon branches from one neuron are guided differentially by Semaphorin3D and transient axonal glycoprotein-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Axons from the retina traverse different molecular territories as they navigate to the tectum. A single territory might span only a few cell diameters and harbour multiple guidance cues, many of which are beginning to be characterized. Also present in the pathway are 'modulators' that influence a growth cone's response to a coincident signal but do not guide growth directly. An emerging principle is that the growth cone, itself, changes molecularly as it journeys through the visual pathway. Growing retinal axons contain mRNAs, ubiquitinating and apoptotic enzymes, translation and degradation machinery. Guidance cues can trigger rapid and local synthesis, degradation and endocytosis of proteins, providing a fast and flexible way for growth cones to respond to cues in their microenvironment and to alter their responsiveness. The data raise the idea that the localized synthesis and downregulation of proteins might help to steer retinal axon growth and, further, might contribute to the changing character of a growth cone as it ages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.