ArticleJournal of virology2004
Patterns of feline immunodeficiency virus multiple infection and genome divergence in a free-ranging population of African lions.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Advancements in veterinary medicine: the use of Flowgy for nasal airflow simulation and surgical predictions in big felids (a case study in lions).Frontiers in veterinary science · 2023Article
- The first feline immunodeficiency virus from Siberian tigers (Panthera tigris altaica) in northeastern China.Archives of virology · 2022Article
- Apathogenic proxies for transmission dynamics of a fatal virus.Frontiers in veterinary science · 2022Article
- Identification of Novel Alleles and Structural Haplotypes of Major Histocompatibility Complex Class I and DRB Genes in Domestic Cat (Frontiers in genetics · 2020Article
- Endemic infection can shape exposure to novel pathogens: Pathogen co-occurrence networks in the Serengeti lions.Ecology letters · 2019Article
- Origin and recent expansion of an endogenous gammaretroviral lineage in domestic and wild canids.Retrovirology · 2019Article
- Viral Restriction Activity of Feline BST2 Is Independent of Its N-Glycosylation and Induction of NF-κB Activation.PloS one · 2015Article
- Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein.Journal of virology · 2012Article
- Emerging viruses in the Felidae: shifting paradigms.Viruses · 2012Review
- The role of BST2/tetherin in feline retrovirus infection.Veterinary immunology and immunopathology · 2011Review
- FIV diversity: FIV Ple subtype composition may influence disease outcome in African lions.Veterinary immunology and immunopathology · 2011Article
- Feline immunodeficiency virus (FIV) in wild Pallas' cats.Veterinary immunology and immunopathology · 2010Article
- Pathological manifestations of feline immunodeficiency virus (FIV) infection in wild African lions.Virology · 2009Article
- Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors.Journal of virology · 2008Article
- The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics.PLoS genetics · 2008Article
- Could FIV zoonosis responsible of the breakdown of the pathocenosis which has reduced the European CCR5-Delta32 allele frequencies?Virology journal · 2008Article
- Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.PloS one · 2008Article
- Evolution of feline immunodeficiency virus in Felidae: implications for human health and wildlife ecology.Veterinary immunology and immunopathology · 2008Review
- FIV cross-species transmission: an evolutionary prospective.Veterinary immunology and immunopathology · 2008Review
- Genomic organization, sequence divergence, and recombination of feline immunodeficiency virus from lions in the wild.BMC genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Feline immunodeficiency virus (FIV) is a lentivirus that causes AIDS-like immunodeficiency disease in domestic cats. Free-ranging lions, Panthera leo, carry a chronic species-specific strain of FIV, FIV-Ple, which so far has not been convincingly connected with immune pathology or mortality. FIV-Ple, harboring the three distinct strains A, B, and C defined by pol gene sequence divergences, is endemic in the large outbred population of lions in the Serengeti ecosystem in Tanzania. Here we describe the pattern of variation in the three FIV genes gag, pol-RT, and pol-RNase among lions within 13 prides to assess the occurrence of FIV infection and coinfection. Genome diversity within and among FIV-Ple strains is shown to be large, with strain divergence for each gene approaching genetic distances observed for FIV between different species of cats. Multiple in fections with two or three strains were found in 43% of the FIV-positive individuals based on pol-RT sequence analysis, which may suggest that antiviral immunity or interference evoked by one strain is not consistently protective against infection by a second. This comprehensive study of FIV-Ple in a free-ranging population of lions reveals a dynamic transmission of virus in a social species that has historically adapted to render the virus benign.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.