Evidence map›Paper›PMID 15016885›Full record

ArticleJournal of virology2004

Both viral and host factors contribute to neurovirulence of bovine herpesviruses 1 and 5 in interferon receptor-deficient mice.

Carlos Abril, Monika Engels, Anne Liman, Monika Hilbe, Sarah Albini, Marco Franchini, Mark Suter, Mathias Ackermann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 99 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Identification ofMicroorganisms · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Viral infections shared between water buffaloes and small ruminants in Switzerland.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Inhibitory effect of silver nanoparticles on bovine herpesvirus-1.International journal of veterinary science and medicine · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Development of a probe based real time PCR assay for detection of bovine herpes virus-1 in semen and other clinical samples.Indian journal of virology : an official organ of Indian Virological Society · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Carlos AbrilInstitute of Virology. Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Monika Engels
Anne Liman
Monika Hilbe
Sarah Albini
Marco Franchini
Mark Suter
Mathias Ackermann
Institute of Virology of the Slovak Academy of Sciences · SKUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herpes simplex virus (HSV) type 1 and bovine herpesviruses 1 and 5 (BHV-1 and BHV-5) can use the same cellular receptor for entry, but only HSV is known to cause disease in mice. We hypothesized that components of either the innate or the adaptive immune system, or a combination of both, were responsible for curbing replication of BHVs in mice. Therefore, wild-type mice as well as mice with various combined genetic deficiencies in the alpha/beta interferon receptor or gamma interferon receptor and in the ability to produce mature B and T lymphocytes (RAG-2 deletion) were infected with BHV-1 and BHV-5 and monitored clinically, serologically, histopathologically, and virologically. A functional immune system protected the mice from disease and death due to BHV infection, and the immune response was Th1 like. BHV-5 was transported to the central nervous system by the axonal pathway, whereas viremia was required for this outcome with BHV-1. The alpha/beta interferon system was able to obstruct quantitative spread of the viruses in the infected organism. The gamma interferon system had a protective effect against BHV-1, even in mice with the RAG-2 deletion. In contrast, the same mice succumbed to neurological disease and death upon infection with BHV-5. Productively infected neurons were detected only in BHV-5-infected mice with an intact gamma interferon system. We conclude that the alpha/beta interferon system had a protective effect, while an intact gamma interferon system was required for efficient replication of BHV-5 in mouse neurons and for the development of neurological disease.

Indexed as

AnimalsAxonal TransportBrainCattleDisease Models, AnimalDNA, ViralHerpesviridae InfectionsHerpesvirus 1, BovineHerpesvirus 5, BovineInterferon-gammaMiceNeuronsReceptors, InterferonTh1 CellsViremiaVirulenceDNA, ViralInterferon-gammaReceptors, Interferon

Identifiers

PMID15016885
PMCPMC371052
OpenAlexW2127117847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.