ArticleGut2004
Dietary fructo-oligosaccharides and inulin decrease resistance of rats to salmonella: protective role of calcium.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 150 citations in OpenAlex.
- Effects of dietary FODMAP content on the faecal microbiome and gastrointestinal physiology in healthy adults: a randomised, controlled cross-over feeding study.The British journal of nutrition · 2025Trial
- Effect of Chicory-derived Inulin on Abdominal Sensations and Bowel Motor Function.Journal of clinical gastroenterology · 2017Trial
- Phytase modulates ileal microbiota and enhances growth performance of the broiler chickens.PloS one · 2015Trial
- Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences.European journal of nutrition · 2009Trial
- The Impact of Pre- and Probiotic Product Combinations on Ex vivo Growth of Avian PathogenicMicroorganisms · 2022Article
- Dietary 25-hydroxycholecalciferol modulates gut microbiota and improves the growth, meat quality, and antioxidant status of growing-finishing pigs.Frontiers in microbiology · 2022Article
- Supplemental Effects of Phytase on Modulation of Mucosa-Associated Microbiota in the Jejunum and the Impacts on Nutrient Digestibility, Intestinal Morphology, and Bone Parameters in Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- Dietary calcium phosphate strongly impacts gut microbiome changes elicited by inulin and galacto-oligosaccharides consumption.Microbiome · 2021Article
- Dietary Inulin IncreasesApplied and environmental microbiology · 2021Article
- Article
- Toxicity of Canola-Derived Glucosinolate Degradation Products in Pigs-A Review.Animals : an open access journal from MDPI · 2020Review
- Prediction of Postoperative Ileus in Patients With Colorectal Cancer by Preoperative Gut Microbiota.Frontiers in oncology · 2020Article
- Insight Into Dynamics of Gut Microbial Community of Broilers Fed With Fructooligosaccharides Supplemented Low Calcium and Phosphorus Diets.Frontiers in veterinary science · 2019Article
- Lactic Acid Treatment of Cereals and Dietary Phytase Modified Fecal Microbiome Composition Without Affecting Expression of Virulence Factor Genes in Growing Pigs.Frontiers in microbiology · 2019Article
- Protective Effects of Xyloglucan in Association with the Polysaccharide Gelose in an Experimental Model of Gastroenteritis and Urinary Tract Infections.International journal of molecular sciences · 2018Article
- Current understanding of microbiota- and dietary-therapies for treating inflammatory bowel disease.Journal of microbiology (Seoul, Korea) · 2018Review
- Dietary changes in nutritional studies shape the structural and functional composition of the pigs' fecal microbiome-from days to weeks.Microbiome · 2017Article
- Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut.Nature microbiology · 2016Article
- Circulating Biomarkers of Gut Barrier Function: Correlates and Nonresponse to Calcium Supplementation among Colon Adenoma Patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2016Article
- Insights into Broilers' Gut Microbiota Fed with Phosphorus, Calcium, and Phytase Supplemented Diets.Frontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have shown recently that rapid fermentable fructo-oligosaccharides (FOS) decreased resistance of rats towards salmonella. It is not known whether inulin (which is fermented more gradually) has similar effects or whether buffering nutrients can counteract the adverse effects of rapid fermentation.
aimsTo compare the effects of dietary inulin and FOS on resistance of rats to Salmonella enterica serovar Enteritidis and to determine whether calcium phosphate counteracts the effects of fermentation.
methodsMale Wistar rats (n = 8 per group) were fed a human "Western style diet". Diets with 60 g/kg cellulose (control), FOS, or inulin had either a low (30 mmol/kg) or high (100 mmol/kg) calcium concentration. After an adaptation period of two weeks, animals were orally infected with 2 x 10(9) colony forming units of Salmonella enterica serovar Enteritidis. Colonisation of salmonella was determined by quantification of salmonella in caecal contents. Translocation of salmonella was quantified by analysis of urinary nitric oxide metabolites in time.
resultsInulin and FOS decreased intestinal pH and increased faecal lactobacilli and enterobacteria. Moreover, both prebiotics increased the cytotoxicity of faecal water and faecal mucin excretion. Both prebiotics increased colonisation of salmonella in caecal contents and enhanced translocation of salmonella. Dietary calcium phosphate counteracted most of the adverse effects of inulin and FOS.
conclusionsBoth inulin and FOS impair resistance to intestinal infections in rats. This impairment is partially prevented by dietary calcium phosphate. The results of the present study await verification in other controlled animal and human studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.