ArticleGut2004
Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
87 citing papers in PubMed, 230 citations in OpenAlex.
- Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: A randomized controlled trial.Physiological reports · 2025Trial
- Effect of Oral Administration ofInternational journal of environmental research and public health · 2022Trial
- Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning.BMC veterinary research · 2015Trial
- A silver-alginate-coated dressing to reduce peripherally inserted central catheter (PICC) infections in NICU patients: a pilot randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2010Trial
- Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.International journal of medical sciences · 2026Review
- Prematurity is a risk factor of disorders of gut-brain interaction in adults: A case-control study.World journal of clinical pediatrics · 2025Article
- Budding baboon blues: the prenatal diet lands a lasting gut punch.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Nutritional interventions to counteract the detrimental consequences of early-life stress.Molecular psychiatry · 2025Review
- Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress.Neurobiology of stress · 2024Article
- Gut microbiota drives colon cancer risk associated with diet: a comparative analysis of meat-based and pesco-vegetarian diets.Microbiome · 2024Article
- Early Life Stress in Mice Leads to Impaired Colonic Corticosterone Production and Prolonged Inflammation Following Induction of Colitis.Inflammatory bowel diseases · 2023Article
- Maternal separation leads to dynamic changes of visceral hypersensitivity and fecal metabolomics from childhood to adulthood.Scientific reports · 2023Article
- Maternal separation and TNBS-induced gut inflammation synergistically alter the sexually differentiated stress response in rats.BioPsychoSocial medicine · 2023Article
- cFOS expression in the prefrontal cortex correlates with altered cerebral metabolism in developing germ-free mice.Frontiers in molecular neuroscience · 2023Article
- Pathophysiological Commonality Between Irritable Bowel Syndrome and Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like Receptor 4-Proinflammatory Cytokine Signaling.Journal of neurogastroenterology and motility · 2022Review
- Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?Cellular and molecular neurobiology · 2022Review
- Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis.Frontiers in neurology · 2022Review
- Acute and Delayed Effects of Stress Eliciting Post-Traumatic Stress-Like Disorder Differentially Alters Fecal Microbiota Composition in a Male Mouse Model.Frontiers in cellular and infection microbiology · 2022Article
- Early Life Exposure to Food Contaminants and Social Stress as Risk Factor for Metabolic Disorders Occurrence?-An Overview.Biomolecules · 2021Review
- Early life stress in mice alters gut microbiota independent of maternal microbiota inheritance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStressful events in the early period of life (for example, maternal deprivation) have been shown to modify adult immune and gastrointestinal tract functions. The present study aimed to establish whether maternal deprivation affects colonic epithelial barrier and the development of an experimental colitis in adult rats.
methodsMale Wistar rat pups were separated during postnatal days 2-14 or left undisturbed with their dam. At 12 weeks of age, we assessed colonic paracellular permeability, bacterial translocation, myeloperoxidase (MPO) activity, mucosal mast cell density, cytokine (interleukin (IL)-1 beta, IL-2, IL-4, IL-10, and interferon gamma (IFN-gamma)) mRNA expression, and macroscopic damage. Total gut permeability, MPO activity, and macroscopic damage were also assessed four days after intracolonic administration of 2,4,6-trinitrobenzenesulphonic acid (TNBS).
resultsMaternal deprivation triggered a significant increase in colonic permeability associated with bacterial translocation into the mesenteric lymph nodes, liver, and spleen. These alterations were associated with some macroscopic damage and an increase in colonic MPO activity, mucosal mast cell density, and cytokine mRNA expression. Intracolonic infusion of TNBS induced a significantly higher inflammatory reaction in separated animals, as judged by enhanced MPO colonic levels, total gut permeability, and macroscopic lesions.
conclusionsMaternal deprivation promotes long term alterations in the colonic epithelial barrier associated with an exaggerated immune response to an external immune stimulus. This suggests a role for early psychological factors in the regulation of colonic mucosal barrier in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.