ArticleGut2004
Intestinal B cell hyperactivity in AIDS is controlled by highly active antiretroviral therapy.
Article in Gut, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Effect of anti-CD4 mAb induced by inhibiting B cell disorder on immune reconstruction of HIV-infected immunological non-responders.Molecular medicine (Cambridge, Mass.) · 2025Article
- Gut Microbiome Homeostasis and the CD4 T- Follicular Helper Cell IgA Axis in Human Immunodeficiency Virus Infection.Frontiers in immunology · 2021Review
- Serum protein electrophoresis pattern in patients living with HIV: frequency of possible abnormalities in Iranian patients.Iranian journal of microbiology · 2019Article
- Distinct systemic microbiome and microbial translocation are associated with plasma level of anti-CD4 autoantibody in HIV infection.Scientific reports · 2018Article
- Pathological Role of Anti-CD4 Antibodies in HIV-Infected Immunologic Nonresponders Receiving Virus-Suppressive Antiretroviral Therapy.The Journal of infectious diseases · 2017Article
- Dysregulation of Systemic and Mucosal Humoral Responses to Microbial and Food Antigens as a Factor Contributing to Microbial Translocation and Chronic Inflammation in HIV-1 Infection.PLoS pathogens · 2017Article
- B-cell responses to HIV infection.Immunological reviews · 2017Review
- CD4Frontiers in immunology · 2016Article
- Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.The Journal of allergy and clinical immunology · 2014Article
- Secretory immunity with special reference to the oral cavity.Journal of oral microbiology · 2013Article
- Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.Retrovirology · 2012Article
- Intraepithelial γδ T cells remain increased in the duodenum of AIDS patients despite antiretroviral treatment.PloS one · 2012Article
- Antigen-dependent and -independent mechanisms of T and B cell hyperactivation during chronic HIV-1 infection.Journal of virology · 2011Review
- Characterising B cell numbers and memory B cells in HIV infected and uninfected Malawian adults.BMC infectious diseases · 2010Article
- Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection.PLoS medicine · 2009Article
- B cells in HIV infection and disease.Nature reviews. Immunology · 2009Review
- Mucosal immunity to HIV: a review of recent literature.Current opinion in HIV and AIDS · 2008Article
- Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease.The Journal of allergy and clinical immunology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well documented that highly active antiretroviral therapy (HAART) restores systemic immunity to human immunodeficiency virus (HIV) but the effect of this treatment on the mucosal immune system is less clear.
aimsBecause future preventive or therapeutic vaccines against HIV may be administered by the mucosal route, we wished to evaluate the effect of HAART on the activation level and homeostasis of the intestinal B cell system. PATIENTS AND
methodsDuodenal biopsy specimens were collected consecutively from infection prone HIV positive adults (n = 31), mostly with advanced AIDS. In situ two colour immunofluorescence staining was performed to quantify mucosal immunoglobulin (Ig) class and subclass producing immunocytes (plasmablasts and plasma cells).
resultsHIV positive patients had, on average, duodenal proportions of IgA (74.6%), IgM (19.5%), and IgG (3.4%) immunocytes similar to median values recorded in 11 HIV seronegative healthy controls but the total immunocyte number per mucosal section length unit (500 microm) was significantly increased in patients (median 175 v 120 cells/unit; p<0.008), mainly comprised of IgA (p<0.02) and IgG1 (median 81.8% of total IgG; p<0.02) isotypes. Patients receiving a successful HAART regimen tended to normalise their IgG1 proportion and showed significantly lower total duodenal IgA immunocyte number than those receiving no or insufficient antiretroviral treatment (p<0.005).
conclusionOur study demonstrated that advanced AIDS patients hyperactivate their intestinal B cell system. HAART could significantly reverse this perturbation, suggesting restored ability of the mucosal immune system to control intestinal infections.
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