ArticleJournal of neuro-oncology2004
Transforming growth factor-beta effects on meningioma cell proliferation and signal transduction pathways.
Article in Journal of neuro-oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Meningioma-Brain Crosstalk: A Scoping Review.Cancers · 2021Article
- Differentially Expressed MicroRNAs in Radioresistant and Radiosensitive Atypical Meningioma: A Clinical Study in Chinese Patients.Frontiers in oncology · 2020Article
- Posttranscriptional deregulation of signaling pathways in meningioma subtypes by differential expression of miRNAs.Neuro-oncology · 2015Article
- Hypoxia inducible factor-1 is involved in growth factor, glucocorticoid and hypoxia mediated regulation of vascular endothelial growth factor-A in human meningiomas.Journal of neuro-oncology · 2014Article
- Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients.Journal of neuro-oncology · 2013Article
- Cerebrospinal fluid stimulates leptomeningeal and meningioma cell proliferation and activation of STAT3.Journal of neuro-oncology · 2012Article
- Analysis of transforming growth factor β receptor expression and signaling in higher grade meningiomas.Journal of neuro-oncology · 2011Article
- Differential expression profiling analyses identifies downregulation of 1p, 6q, and 14q genes and overexpression of 6p histone cluster 1 genes as markers of recurrence in meningiomas.Neuro-oncology · 2010Article
- Aberrant signaling pathways in meningiomas.Journal of neuro-oncology · 2010Review
- Medical therapies for meningiomas.Journal of neuro-oncology · 2010Review
- Molecular signatures define two main classes of meningiomas.Molecular cancer · 2007Article
- TGF-beta expression during rat pregnancy and activity on decidual cell survival.Reproductive biology and endocrinology : RB&E · 2005Article
- Meningiomas and Proteomics: Focus on New Potential Biomarkers and Molecular Pathways.Cancer genomics & proteomicsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of transforming growth factor-beta (TGF-beta) in regulation of meningioma growth and intracellular events transducing its signals are not established. In this study, we evaluated the effects of TGF-beta1 on basal meningioma cell proliferation in 10 primary human meningioma cell cultures and whether TGF-beta's signals are transduced by the Smad 2/3, MAPK/Erk kinase-1 (MEK-1)-mitogen-activated protein kinase (MAPK), Akt-p70(S6K) or p38-JUNK pathways in 5. We also tested whether neutralizing antibodies to TGF-beta alter CSF stimulation of meningioma cell proliferation. On average, TGF-beta reduced meningioma cell [3H]-thymidine incorporation to 58% of controls at 24% and to 61% of controls at 36 h. TGF-beta inhibition of meningioma cell proliferation was associated with a suggestion increased phosphorylation of Smad 2/3 in 2 cases and high basal phosphorylation in 3 but no change in activation of the MEK-1-MAPK, Akt-p70(S6K) or p38-JUNK pathways. As shown previously, CSF stimulated meningioma cell proliferation in the 3 cultures tested. Neutralizing antibody against TGF-beta augmented this stimulation in 2 of 3 cultures. These findings suggest that TGF-beta exerts a largely inhibitory effect on basal meningioma proliferation, perhaps in part through Smad 2/3.
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