ArticleJournal of cancer research and clinical oncology2004
Carcinogenic potential of tobacco tar-resistant Staphylococcus aureus in buccal cavity.
Article in Journal of cancer research and clinical oncology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Prevalence and antibiotic resistance ofFrontiers in cellular and infection microbiology · 2023Article
- Bidirectional Functional Effects ofMicroorganisms · 2022Review
- Role of microbial dysbiosis in carcinogenesis & cancer therapies.The Indian journal of medical research · 2020Review
- Challenging the effectiveness of green tea in primary and tertiary cancer prevention.Journal of cancer research and clinical oncology · 2012Review
- New tumor necrosis factor-alpha-inducing protein released from Helicobacter pylori for gastric cancer progression.Journal of cancer research and clinical oncology · 2005Article
- CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells.OncoimmunologyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effects of cigarette smoking on the association between inflammation and cancer were studied, since some bacteria induce the production of tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine and endogenous tumor promoter, in cells.
methodsBacteria from a gargled solution from the buccal cavity of 20 individuals were cultured in the presence of 4 mg/ml cigarette-smoke condensates. Although cigarette-smoke condensates inhibited growth of Staphylococcus aureus strongly and that of Staphylococcus warneri weakly, tobacco tar-resistant S. aureus and S. warneri were obtained.
resultsOne tobacco tar-resistant S. aureus strain (Sa-TA10) induced expression of the TNF-alpha gene in both Bhas 42 cells (v-Ha-ras transfected BALB/3T3 cells) and human lung cancer cell line H226B, while one tobacco tar-resistant S. warneri (Sw-TA75) did not induce it significantly. Moreover, Sa-TA10 induced formation of transformed foci and soft-agar colony in Bhas 42 cells in cooperation with the v-Ha-ras gene. The results suggested that Sa-TA10 has carcinogenic potential, whereas Sw-TA75 does not.
conclusionThese data suggest that tobacco tar-resistant S. aureus, with carcinogenic potential, is present in the buccal cavity of some individuals, and that cigarette smoking simultaneously inhibits growth of most of the bacteria and selects carcinogenic bacteria.
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