Evidence map›Paper›PMID 15014625›Full record

ArticlePrimary care companion to the Journal of clinical psychiatry2001

SSRI Antidepressant Medications: Adverse Effects and Tolerability.

James M. Ferguson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Primary care companion to the Journal of clinical psychiatry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 307 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
307citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

307 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  14. The efficacy of adjunctiveThe British journal of psychiatry : the journal of mental science · 2025
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247 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James M. FergusonUniversity of Utah, School of Medicine, Pharmacology Research Clinic, Salt Lake City.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Side effects of antidepressants can be predicted by receptor selectivity and site of action. Although the selective serotonin reuptake inhibitors (SSRIs) have better overall safety and tolerability than older antidepressants, broad-based experience with SSRIs has shown the frequency and type of side effects to be increased relative to clinical trial data. The author explores the reasons for the different profiles and discusses adverse effects, especially sexual dysfunction, weight gain, and sleep disturbance, the most troubling adverse events seen during long-term SSRI therapy. The informed management of these side effects by primary care practitioners supports successful treatment of depression.

Identifiers

PMID15014625
PMCPMC181155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.