ArticleThe EMBO journal2004
Combinatorial gene control involving E2F and E Box family members.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
- Clinicopathological features and prognosis of TFE3-positive renal cell carcinoma.Frontiers in oncology · 2022Article
- Long Non-Coding RNA LINC02747 Promotes the Proliferation of Clear Cell Renal Cell Carcinoma by Inhibiting miR-608 and Activating TFE3.Frontiers in oncology · 2020Article
- MicroRNA profiles in B-cell non-Hodgkin lymphoma.EJIFCC · 2019Review
- Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- ASPL-TFE3 Oncoprotein Regulates Cell Cycle Progression and Induces Cellular Senescence by Up-Regulating p21.Neoplasia (New York, N.Y.) · 2016Article
- Identification of B cells as a major site for cyprinid herpesvirus 3 latency.Journal of virology · 2014Article
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- Cis-regulatory elements are harbored in Intron5 of the RUNX1 gene.BMC genomics · 2014Article
- Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancers.BMC genomics · 2013Article
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- Article
- Wide-ranging functions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis.Nucleic acids research · 2011Article
- Genome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome.The Journal of biological chemistry · 2011Article
- G1 arrest and differentiation can occur independently of Rb family function.The Journal of cell biology · 2010Article
- MicroRNA: Biogenesis, Function and Role in Cancer.Current genomics · 2010Article
- Genome-wide analysis of YY2 versus YY1 target genes.Nucleic acids research · 2010Article
- The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system.Nature reviews. Cancer · 2008Review
- Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters.Oncogene · 2008Article
- Article
- p110 CUX1 cooperates with E2F transcription factors in the transcriptional activation of cell cycle-regulated genes.Molecular and cellular biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various studies point to the potential role of combinatorial action of transcription factors as a mechanism to achieve the complexity of eukaryotic gene control with a finite number of regulatory proteins. Our previous work has focused on interactions involving the E2F family of transcription factors as an example of combinatorial gene control, leading to the identification of TFE3 and YY1 as transcription partners for several E2F proteins. We now show that additional E2F target genes share a common promoter architecture and are also regulated by the combined action of TFE3 and E2F3. In contrast, the thymidine kinase (TK-1) promoter is also regulated by E2F3 but independent of TFE3. Other promoters exhibit distinct specificity in the interaction with E2F proteins that includes a role for E2F1 but not E2F3, examples where both E2F1 and E2F3 are seen to interact, and promoters that are regulated by TFE3 but independent of an E2F. We propose that these examples of combinatorial interactions involving E2F proteins provide a basis for the specificity of transcription control in the Rb/E2F pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.