ArticleThe EMBO journal2004
Dynacortin contributes to cortical viscoelasticity and helps define the shape changes of cytokinesis.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 75 citations in OpenAlex.
- The lectin Discoidin I acts in the cytoplasm to help assemble the contractile machinery.The Journal of cell biology · 2022Article
- Seeing is believing: tools to study the role of Rho GTPases during cytokinesis.Small GTPases · 2022Review
- Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis.Nature communications · 2021Article
- Bioenergetics of theBiomolecules · 2020Article
- Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages.Frontiers in cell and developmental biology · 2020Article
- Network Contractility During Cytokinesis-from Molecular to Global Views.Biomolecules · 2019Review
- Article
- Micropipette Aspiration of Oocytes to Assess Cortical Tension.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The fifth sense: Mechanosensory regulation of alpha-actinin-4 and its relevance for cancer metastasis.Seminars in cell & developmental biology · 2017Review
- Myosin-independent cytokinesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mechanochemical Signaling Directs Cell-Shape Change.Biophysical journal · 2017Review
- Mechanics and stability of vesicles and droplets in confined spaces.Physical review. E · 2016Article
- Cytokinesis: Robust cell shape regulation.Seminars in cell & developmental biology · 2016Review
- Mechanical stress and network structure drive protein dynamics during cytokinesis.Current biology : CB · 2015Article
- Biochemical and biological properties of cortexillin III, a component of Dictyostelium DGAP1-cortexillin complexes.Molecular biology of the cell · 2014Article
- Mimicking the mechanical properties of the cell cortex by the self-assembly of an actin cortex in vesicles.Applied physics letters · 2014Article
- Anillin-dependent organization of septin filaments promotes intercellular bridge elongation and Chmp4B targeting to the abscission site.Open biology · 2014Article
- Molecular mechanisms of cellular mechanosensing.Nature materials · 2013Article
- Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy.Biology of reproduction · 2013Article
- Delineating the core regulatory elements crucial for directed cell migration by examining folic-acid-mediated responses.Journal of cell science · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
During cytokinesis, global and equatorial pathways deform the cell cortex in a stereotypical manner, which leads to daughter cell separation. Equatorial forces are largely generated by myosin-II and the actin crosslinker, cortexillin-I. In contrast, global mechanics are determined by the cortical cytoskeleton, including the actin crosslinker, dynacortin. We used direct morphometric characterization and laser-tracking microrheology to quantify cortical mechanical properties of wild-type and cortexillin-I and dynacortin mutant Dictyostelium cells. Both cortexillin-I and dynacortin influence cytokinesis and interphase cortical viscoelasticity as predicted from genetics and biochemical data using purified dynacortin proteins. Our studies suggest that the regulation of cytokinesis ultimately requires modulation of proteins that control the cortical mechanical properties that establish the force-balance that specifies the shapes of cytokinesis. The combination of genetic, biochemical, and biophysical observations suggests that the cell's cortical mechanical properties control how the cortex is remodeled during cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.