ArticleGenes and immunity2004
Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients.
Article in Genes and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis.PloS one · 2019Pooled it
- Article
- The Limitation of HLA Diversity as a Risk Factor for Pediatric-Onset Autoimmune Rheumatic Disease.Journal of clinical medicine · 2025Article
- Frequency of celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with celiac disease.World journal of clinical pediatrics · 2022Article
- Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.Nutrients · 2020Article
- Gut microbiota in Celiac Disease: microbes, metabolites, pathways and therapeutics.Expert review of clinical immunology · 2020Review
- Role of Lactulose Rhamnose Permeability Test in Assessing Small Bowel Mucosal Damage in Children with Celiac Disease.Global pediatric health · 2020Article
- The roles of MHC class II genes and post-translational modification in celiac disease.Immunogenetics · 2017Review
- Celiac Disease: Role of the Epithelial Barrier.Cellular and molecular gastroenterology and hepatology · 2017Review
- Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease.Autoimmune diseases · 2016Article
- Impact on parents of HLA-DQ2/DQ8 genotyping in healthy children from coeliac families.European journal of human genetics : EJHG · 2015Article
- Pathophysiology of celiac disease.Gastrointestinal endoscopy clinics of North America · 2012Review
- Celiac disease in children and adolescents: special considerations.Seminars in immunopathology · 2012Review
- Regulation of major histocompatibility complex class II gene expression, genetic variation and disease.Genes and immunity · 2010Review
- Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.Clinical and experimental immunology · 2008Review
- Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.PloS one · 2008Article
- HLA DQ gene dosage and risk and severity of celiac disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2007Article
- CTLA4 is differentially associated with autoimmune diseases in the Dutch population.Human genetics · 2005Article
- HLA and disease.European journal of epidemiology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major genetic susceptibility to coeliac disease is contributed by the human leukocyte antigen (HLA) region. The primary association is with the HLA-DQ2 molecule, encoded by the DQA1*05 and DQB1*02 alleles, which is expressed by over 90% of patients. The aim of our study was to perform an extensive scan of the entire HLA region to determine whether there is evidence for the presence of additional HLA susceptibility genes for coeliac disease in the Dutch population, acting independently of DQ2. In all, 16 microsatellite markers and the DQA1 and DQB1 genes were genotyped in simplex cis DQ2-positive coeliac disease families and cis DQ2-positive control families. Allele frequencies of markers on phase-known DQ2-positive haplotypes transmitted to patients were compared to a combined group of DQ2-positive nontransmitted and control haplotypes, thereby controlling for the DQ2 contribution. No significant differences at any of the marker loci were detected, suggesting that DQ2 is the major HLA risk factor for coeliac disease. Individuals homozygous for DQ2 or heterozygous for DQA1*05-DQB1*02/DQA1*0201-DQB1*02 were found to be at five-fold increased risk for development of coeliac disease (P<10(-8)). This risk seems to be conferred by the presence of a second DQB1*02 allele next to one DQA1*05-DQB1*02 haplotype, independently of the second DQA1 allele.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.