ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Role of calcium in neurotensin-evoked enhancement in firing in mesencephalic dopamine neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- RNA-seq Analysis Reveals Neuroimmune Remodeling and NTSR1-Related Neuroactive Signatures After Combined rTMS and Press-Tack Needle Stimulation in TBI Rats.Journal of molecular neuroscience : MN · 2026Article
- Influence of the neurotensin signaling system on feeding and satiety.Neuropharmacology · 2025Review
- Article
- Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens.Neuropharmacology · 2023Article
- The Role of Intra-Amygdaloid Neurotensin and Dopamine Interaction in Spatial Learning and Memory.Biomedicines · 2022Article
- The Role of Central Neurotensin in Regulating Feeding and Body Weight.Endocrinology · 2021Review
- Association of Neurotensin Receptor 1 Gene Polymorphisms With Defense Mechanisms in Healthy Chinese.Frontiers in psychiatry · 2021Article
- Dopamine D2 autoreceptor interactome: Targeting the receptor complex as a strategy for treatment of substance use disorder.Pharmacology & therapeutics · 2020Review
- β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.Cell · 2020Article
- Diverse actions of the modulatory peptide neurotensin on central synaptic transmission.The European journal of neuroscience · 2019Review
- Lateral hypothalamic neurotensin neurons promote arousal and hyperthermia.PLoS biology · 2019Article
- Determination of neurotensin projections to the ventral tegmental area in mice.Neuropeptides · 2018Article
- Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms.Cell reports · 2017Article
- Repeated ventral midbrain neurotensin injections sensitize to amphetamine-induced locomotion and ERK activation: A role for NMDA receptors.Neuropharmacology · 2017Article
- Neurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons.Journal of neurophysiology · 2015Article
- Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Review
- Association between neurotensin receptor 1 gene polymorphisms and alcohol dependence in a male Han Chinese population.Journal of molecular neuroscience : MN · 2013Article
- Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity.Molecular metabolism · 2013Article
- Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.Neurochemical research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotensin (NT) increases neurotransmission within the mesolimbic dopamine system by enhancing the firing rate of dopaminergic (DAergic) neurons and by acting at the nerve terminal level. The signal transduction pathways involved in these effects have not been characterized, but NT receptors are coupled to the phospholipase C pathway and Ca(2+) mobilization. However, an enhancement of intracellular Ca(2+) concentration ([Ca(2+)](i)) evoked by NT in DAergic neurons has yet to be demonstrated. Furthermore, the hypothesis that the excitatory effects of NT in DAergic neurons are Ca(2+) dependent is currently untested. In whole-cell recording experiments, DAergic neurons in culture were identified by their selective ability to express a cell-specific green fluorescent protein reporter construct. These experiments confirmed that NT increases firing rate in cultured DAergic neurons. This effect was Ca(2+) dependent because it was blocked by intracellular dialysis with BAPTA. Using Ca(2+) imaging, we showed that NT caused a rapid increase in [Ca(2+)](i) in DAergic neurons. Most of the Ca(2+) originated from the extracellular medium. NT-induced excitation and Ca(2+) influx were blocked by SR48692, an antagonist of the type 1 NT receptor. Blocking IP(3) receptors using heparin prevented the excitatory effect of NT. Moreover, Zn(2+) and SKF96365 both blocked the excitatory effect of NT, suggesting that nonselective cationic conductances are involved. Finally, although NT can also induce a rise in [Ca(2+)](i) in astrocytes, we find that NT-evoked excitation of DAergic neurons can occur independently of astrocyte activation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.