ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Synaptic vesicles: test for a role in presynaptic calcium regulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Optimal neuromuscular performance requires motor neuron phosphagen kinases.The Journal of physiology · 2026Article
- Mitochondrial phosphagen kinases support the volatile power demands of motor nerve terminals.The Journal of physiology · 2023Article
- The Putative Drosophila TMEM184B Ortholog Tmep Ensures Proper Locomotion by Restraining Ectopic Firing at the Neuromuscular Junction.Molecular neurobiology · 2022Article
- Neto-α Controls Synapse Organization and Homeostasis at the Drosophila Neuromuscular Junction.Cell reports · 2020Article
- Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila.Neuron · 2017Article
- NaThe Journal of physiology · 2017Article
- High-Probability Neurotransmitter Release Sites Represent an Energy-Efficient Design.Current biology : CB · 2016Article
- Article
- Synaptic neuropeptide release by dynamin-dependent partial release from circulating vesicles.Molecular biology of the cell · 2015Article
- A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.PLoS biology · 2015Article
- Cholesterol and F-actin are required for clustering of recycling synaptic vesicle proteins in the presynaptic plasma membrane.The Journal of physiology · 2014Article
- CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning.Frontiers in molecular neuroscience · 2013Article
- Optimization of a GCaMP calcium indicator for neural activity imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Glial processes at the Drosophila larval neuromuscular junction match synaptic growth.PloS one · 2012Article
- Vesicular sterols are essential for synaptic vesicle cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Presynaptic mitochondria in functionally different motor neurons exhibit similar affinities for Ca2+ but exert little influence as Ca2+ buffers at nerve firing rates in situ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
- Visualizing the live Drosophila glial-neuromuscular junction with fluorescent dyes.Journal of visualized experiments : JoVE · 2009Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Membrane-bound organelles such as mitochondria and the endoplasmic reticulum play an important role in neuronal Ca(2+) homeostasis. Synaptic vesicles (SVs), the organelles responsible for exocytosis of neurotransmitters, occupy more of the volume of presynaptic nerve terminals than any other organelle and, under some conditions, can accumulate Ca(2+). They are also closely associated with voltage-gated Ca(2+) channels (VGCCs) that trigger transmitter release by admitting Ca(2+) into the nerve terminal in response to action potentials (APs). We tested the hypothesis that SVs can modulate Ca(2+) signals in the presynaptic terminal. This has been a difficult question to address because neither pharmacological nor genetic approaches to block Ca(2+) permeation of the SV membrane have been available. To investigate the possible role of SVs in Ca(2+) regulation, we used imaging techniques to compare Ca(2+) dynamics in motor nerve terminals before and after depletion of SVs. We used the temperature-sensitive Drosophila dynamin mutant shibire, in which SVs can be eliminated by stimulation. There was no difference in the amplitude or time course of Ca(2+) responses during high-frequency trains of APs, or single APs, in individual presynaptic boutons before and after depletion of SVs. SVs have a limited role, if any, in the rapid sequestration of Ca(2+) within the neuronal cytosol or the synaptic microdomain. We also conclude that SVs are not important for regulation of synaptic VGCCs.
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