ArticleGenes & development2004
Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase.
Article in Genes & development, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 264 citations in OpenAlex.
- Extracellular Redox Balance as a Determinant of Immune Regulation and Tissue Inflammation.Antioxidants (Basel, Switzerland) · 2026Review
- Beyond Radical Scavengers: Focus on NADPH Oxidases (NOX) Inhibitors as New Agents for Antioxidant Therapy in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Nox3 expression and function in retinal ganglion cells and Amacrine cells.Cellular and molecular life sciences : CMLS · 2025Article
- Evaluation of the vestibulo-ocular reflex in head-tilt mutant mice.Biochemistry and biophysics reports · 2025Article
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Navigating redox imbalance: the role of oxidative stress in embryonic development and long-term health outcomes.Frontiers in cell and developmental biology · 2025Review
- Increased Homer Activity and NMJ Localization in the Vestibular LesionInternational journal of molecular sciences · 2024Article
- Focused Update on Clinical Testing of Otolith Organs.Audiology research · 2024Review
- Gene Expression and Prognostic Value of NADPH Oxidase Enzymes in Breast Cancer.International journal of molecular sciences · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Behavioral and neural responses to high-strength magnetic fields are reduced in otolith mutant mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Factors Influencing Tissue Cyst Yield in a Murine Model of Chronic Toxoplasmosis.Infection and immunity · 2023Article
- Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke.Antioxidants (Basel, Switzerland) · 2022Review
- NADPH Oxidases in Aortic Aneurysms.Antioxidants (Basel, Switzerland) · 2022Review
- Uneven Effects of Sleep Apnea on Semicircular Canals and Otolithic Organs.Frontiers in neurology · 2022Article
- Development andFrontiers in neurology · 2022Article
- NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss.Frontiers in cell and developmental biology · 2022Article
- A Review on Recent Advancement on Age-Related Hearing Loss: The Applications of Nanotechnology, Drug Pharmacology, and Biotechnology.Pharmaceutics · 2021Review
- Nox3-Derived Superoxide in Cochleae Induces Sensorineural Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Therapeutic Value of Single Nucleotide Polymorphisms on the Efficacy of New Therapies in Patients with Multiple Sclerosis.Journal of personalized medicine · 2021Review
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vestibular system of the inner ear is responsible for the perception of motion and gravity. Key elements of this organ are otoconia, tiny biomineral particles in the utricle and the saccule. In response to gravity or linear acceleration, otoconia deflect the stereocilia of the hair cells, thus transducing kinetic movements into sensorineural action potentials. Here, we present an allelic series of mutations at the otoconia-deficient head tilt (het) locus, affecting the gene for NADPH oxidase 3 (Nox3). This series of mutations identifies for the first time a protein with a clear enzymatic function as indispensable for otoconia morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.