ArticleProceedings of the National Academy of Sciences of the United States of America2004
Identification of the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 154 citations in OpenAlex.
- Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp.FEBS letters · 2025Article
- How to quantify magic spots - a brief overview of (p)ppGpp detection and quantitation methods.Frontiers in molecular biosciences · 2025Review
- ppGpp accumulation reduces the expression of the global nitrogen homeostasis-modulating NtcA regulon by affecting 2-oxoglutarate levels.Communications biology · 2023Article
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- Bacterial Pathogen Infection Triggers Magic Spot Nucleotide Signaling inJournal of the American Chemical Society · 2023Article
- New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae.The New phytologist · 2023Review
- Identification, characterization and expression analysis of wheat RSH family genes under abiotic stress.Frontiers in plant science · 2023Article
- New seed coating containingPeerJ · 2023Article
- The Importance of Microorganisms for Sustainable Agriculture-A Review.Metabolites · 2022Review
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- Co-crystalization reveals the interaction between AtYchF1 and ppGpp.Frontiers in molecular biosciences · 2022Article
- A Novel Guanine Elicitor Stimulates Immunity inFrontiers in plant science · 2022Article
- Identification of a RelA/SpoT Homolog and Its Possible Role in the Accumulation of Astaxanthin inFrontiers in plant science · 2022Article
- In Silico Study of theInternational journal of molecular sciences · 2021Article
- ppGpp influences protein protection, growth and photosynthesis in Phaeodactylum tricornutum.The New phytologist · 2021Article
- Validation of Omega Subunit of RNA Polymerase as a Functional Entity.Biomolecules · 2020Review
- Arabidopsis Plastid-RNA Polymerase RPOTp Is Involved in Abiotic Stress Tolerance.Plants (Basel, Switzerland) · 2020Article
- Stringent Response Regulates Stress Resistance in CyanobacteriumFrontiers in microbiology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stringent control mediated by the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) is a key regulatory process governing bacterial gene expression. By devising a system to measure ppGpp in plants, we have been able to identify ppGpp in the chloroplasts of plant cells. Levels of ppGpp increased markedly when plants were subjected to such biotic and abiotic stresses as wounding, heat shock, high salinity, acidity, heavy metal, drought, and UV irradiation. Abrupt changes from light to dark also caused a substantial elevation in ppGpp levels. In vitro, chloroplast RNA polymerase activity was inhibited in the presence of ppGpp, demonstrating the existence of a bacteria-type stringent response in plants. Elevation of ppGpp levels was elicited also by treatment with plant hormones jasmonic acid, abscisic acid, and ethylene, but these effects were blocked completely by another plant hormone, indole-3-acetic acid. On the basis of these findings, we propose that ppGpp plays a critical role in systemic plant signaling in response to environmental stresses, contributing to the adaptation of plants to environmental changes.
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