Evidence map›Paper›PMID 15009423›Full record

ReviewImmunology2004

The influence of follicular migration on T-cell differentiation.

Karen M Smith, James M Brewer, Allan Mci Mowat, Yacov Ron, Paul Garside

Abstract readReview
In one paragraph

Review in Immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karen M SmithDivision of Immunology, Infection and Inflammation, Western Infirmary, University of Glasgow, Glasgow G11 6NT, Scotland, UK.
James M Brewer
Allan Mci Mowat
Yacov Ron
Paul Garside

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sequence of events that leads to the development of a T-dependent B-cell response has been studied for many years and much attention has focused on the importance of these interactions for the B cell and the antibody response. While a role for B cells in T-cell memory has been demonstrated, the cellular and molecular mechanisms underlying this are unclear and the importance for T cells to migrate into follicles and interact with B cells has received relatively little attention. These interactions between T and B lymphocytes are facilitated by a co-ordinated series of migration events within lymph nodes and here we propose that this migration and these events are essential for the terminal differentiation of all CD4+ T cells and without it tolerance may result.

Indexed as

AnimalsAntibody FormationB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationCell MovementHumansImmune ToleranceImmunity, CellularImmunologic MemoryLymph NodesMiceModels, ImmunologicalT-Lymphocytes

Identifiers

PMID15009423
PMCPMC1782427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.