ArticleClinical and experimental immunology2004
Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- AAV-mediated in vivo CAR gene therapy for targeting human T-cell leukemia.Blood cancer journal · 2021Article
- Unexpected combination: DiGeorge syndrome and myeloperoxidase deficiency.BMJ case reports · 2020Article
- Effects of eldecalcitol and ibandronate on secondary osteoporosis and muscle wasting in rats with adjuvant-induced arthritis.Osteoporosis and sarcopenia · 2018Article
- Preclinical targeting of human T-cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells.Leukemia · 2016Article
- Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase.Journal of immunology research · 2016Review
- Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production.Arthritis research & therapy · 2015Article
- 1,25-Dihydroxyvitamin D3 prevents bone loss of the secondary spongiosa in arthritic rats by an increase of bone formation and mineralization and inhibition of bone resorption.BMC musculoskeletal disorders · 2014Article
- The role of total and cartilage-specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis.Arthritis research & therapy · 2014Article
- MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination.Stem cells (Dayton, Ohio) · 2012Article
- Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigen-induced arthritis.BMC musculoskeletal disorders · 2010Article
- Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis.Arthritis research & therapy · 2010Article
- Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.Immunology · 2008Article
- Th1/Th2 cytokine ratio in tissue transudates from patients with oral lichen planus.Mediators of inflammation · 2007Article
- Attenuation of murine antigen-induced arthritis by treatment with a decoy oligodeoxynucleotide inhibiting signal transducer and activator of transcription-1 (STAT-1).Arthritis research & therapy · 2006Article
- NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis.The Journal of clinical investigation · 2005Article
- The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells.Arthritis research & therapy · 2005Article
- Expression of cytokine mRNA and protein in joints and lymphoid organs during the course of rat antigen-induced arthritis.Arthritis research & therapy · 2005Article
- Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen induced arthritis: influence on macrophage activation.Annals of the rheumatic diseases · 2004Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the effects of anti-CD4 mAb treatment in acute and chronic antigen-induced arthritis (AIA), C57BL/6 mice were treated intraperitoneally either with the depleting anti-CD4 mAb GK1.5 or with rat-IgG (control) on Days -1, 0, 1, 3, 5, and 7. Arthritis was monitored by assessment of joint swelling and histological evaluation in the acute (Day 3) and the chronic phase (Day 21) of AIA. To determine the effects on cellular immune responses, in vivo T-cell reactivity (delayed type hypersensitivity; DTH) was measured, as well as protein levels of TH1- (IL-2, IFN-gamma) and TH2-cytokines (IL-4, IL-10) in joint extracts and supernatants of ex vivo stimulated spleen and lymph node cells. The humoral immune response was analysed by measuring serum antibodies against methylated bovine serum albumine (mBSA) and extracellular matrix proteins. Treatment with GK1.5 reduced swelling, inflammation, and destruction of the arthritic joint. Unexpectedly, the effects were even more pronounced in the acute than in the chronic phase. The anti-inflammatory effect was accompanied by a diminished DTH against the arthritogen mBSA and a decrease of TH1-cytokine production in spleen and pooled body lymph nodes, whereas the TH2-cytokine production in these organs was unchanged and the humoral immune response was only moderately reduced. There was a failure of depleting CD4+ T-cells in the joint, reflected also by unchanged local cytokine levels. Therefore, systemic rather than local effects on the TH1/TH2 balance appear to underlie the therapeutic efficacy of anti-CD4 treatment in AIA.
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