ArticleThe Journal of experimental medicine1992
Natural occurrence and origin of somatically mutated memory B cells in mice.
Article in The Journal of experimental medicine, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 69 citations in OpenAlex.
- Differences in mouse and human nonmemory B cell pools.Journal of immunology (Baltimore, Md. : 1950) · 2014Trial
- Do Memory B Cells Form Secondary Germinal Centers? Yes and No.Cold Spring Harbor perspectives in biology · 2018Review
- CD73 expression identifies a subset of IgMImmunology · 2017Article
- Heterogeneity in the differentiation and function of memory B cells.Trends in immunology · 2012Review
- A germinal center-independent pathway generates unswitched memory B cells early in the primary response.The Journal of experimental medicine · 2012Article
- Article
- Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization.The Journal of experimental medicine · 2005Article
- Immunoglobulin VH-gene usage of autoantibodies in mercuric chloride-induced membranous glomerulopathy in the rat.Immunology · 2001Article
- Indirect and direct evidence for DNA double-strand breaks in hypermutating immunoglobulin genes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Article
- Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.The Journal of experimental medicine · 1998Article
- B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice.The Journal of experimental medicine · 1998Article
- The role of germinal centers for antiviral B cell responses.Immunologic research · 1998Review
- Delineation of producing ability of IgG and IgA subclasses by naive B cells in newborn infants and adult individuals.Clinical and experimental immunology · 1995Article
- Human lactoferrin induces phenotypic and functional changes in murine splenic B cells.Immunology · 1995Article
- Burkitt's lymphoma is a malignancy of mature B cells expressing somatically mutated V region genes.Molecular medicine (Cambridge, Mass.) · 1995Article
- Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes.The Journal of experimental medicine · 1995Article
- Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.The Journal of experimental medicine · 1994Article
- Analysis of somatic mutation in five B cell subsets of human tonsil.The Journal of experimental medicine · 1994Article
- In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.The Journal of experimental medicine · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While most murine peripheral B cells express germline-encoded antibodies of classes M and D (mu+ delta+ cells), small numbers of memory B cells expressing somatically mutated immunoglobulin G antibodies are generated upon T cell-dependent immunization. Analyzing the antibody repertoire of the mu-delta- B cell pool in unimmunized mice, we show that these cells express somatically mutated VH genes and that most of these genes derive from a set of germline VH genes dominantly expressed by mu+delta+ B cells. Thus, class-switched memory B cells are generated in the absence of intentional immunization, presumably in response to environmental antigens. These cells are either recruited from mu+delta+ B cells or selected from newly arising B cells in parallel to the latter, by the same antigens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.