ArticleJournal of molecular evolution2003
Evolutionary dynamics of the DM domain gene family in metazoans.
Article in Journal of molecular evolution, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 138 citations in OpenAlex.
- A panoramic view of the expression and function of the Doublesex/DMRT gene family inScience advances · 2026Article
- Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system.Biology of sex differences · 2026Article
- Genome-wide investigation of the dmrt gene family reveals new insight into the gonad development in Plectropomus leopardus: dmrt2a regulate the development of oocytes.Biology of sex differences · 2025Article
- Familial DMRT1-related non-obstructive azoospermia: a case report.Journal of assisted reproduction and genetics · 2024Article
- Analyses of theFrontiers in physiology · 2023Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
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- Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic.Journal of clinical medicine · 2020Review
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- Comparative Genomics Studies on theFrontiers in genetics · 2020Article
- Genome-Wide identification of doublesex and Mab-3-Related transcription factor (DMRT) genes in nile tilapia (Biotechnology reports (Amsterdam, Netherlands) · 2019Article
- Identification of sex determination genes and their evolution in Phlebotominae sand flies (Diptera, Nematocera).BMC genomics · 2019Article
- Phylogenetic analysis and embryonic expression of panarthropod Dmrt genes.Frontiers in zoology · 2019Article
- Endodermal pouch-expressedBiology open · 2018Article
- Doublesex Evolution Is Correlated with Social Complexity in Ants.Genome biology and evolution · 2018Article
- Identification of genes involved in gonadal sex differentiation and the dimorphic expression pattern in Takifugu rubripes gonad at the early stage of sex differentiation.Fish physiology and biochemistry · 2018Article
- Sequencing and De Novo Assembly of the Gonadal Transcriptome of the Endangered Chinese Sturgeon (Acipenser sinensis).PloS one · 2015Article
- The low expression of Dmrt7 is associated with spermatogenic arrest in cattle-yak.Molecular biology reports · 2014Article
- Pan-metazoan phylogeny of the DMRT gene family: a framework for functional studies.Development genes and evolution · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The DM domain gene family encodes putative transcription factors related to the sexual regulators Doublesex from Drosophila melanogaster and MAB-3 from Caenorhabditis elegans. While some DM domain proteins are involved in sexual development in very distant metazoan phyla and one in somite development, the function of the great majority of them remains unclear. DM domain genes underwent frequent independent events of gene duplication during the course of evolution and the number of DM domain genes differs between phyla. Variation is even observed within the vertebrate lineage, where some genes present in mammals are absent from fish and vice versa. Of particular interest is the very recent duplication of the DM domain gene dtmrt1 that apparently led to the formation of the master male-determining gene in the medaka fish but not in more divergent fish species. Hence, the DM domain gene family undergoes an important evolutionary turnover probably associated in some cases with novel expression patterns and possibly with new functions. Here we examine the current classification of vertebrate DM domain dmrt genes based on structural features, and propose a simpler nomenclature for dmrt genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.