ArticlePediatric nephrology (Berlin, Germany)2004
Interstitial nephritis from mesalazine: case report and literature review.
Article in Pediatric nephrology (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- 5-ASA induced interstitial nephritis in patients with inflammatory bowel disease: a systematic review.European journal of medical research · 2022Pooled it
- Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis.The Cochrane database of systematic reviews · 2020Pooled it
- Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis.The Cochrane database of systematic reviews · 2016Pooled it
- Curcumin for maintenance of remission in ulcerative colitis.The Cochrane database of systematic reviews · 2012Pooled it
- Extraintestinal Manifestations of Inflammatory Bowel Disease: A Focus on Kidney Complications.International journal of molecular sciences · 2026Review
- Progress in the Treatment of Ulcerative Colitis by Targeting NLRP3 Inflammasome.Drug design, development and therapy · 2026Review
- Insights into renal and urological complications of inflammatory bowel disease.World journal of nephrology · 2024Review
- Kidney Diseases Associated With Inflammatory Bowel Disease: Impact of Chronic Histologic Damage, Treatments, and Outcomes.Kidney international reports · 2024Article
- Granulomatous interstitial nephritis in a treatment-naïve patient with ulcerative colitis.Renal failure · 2022Article
- Renal Manifestations in Inflammatory Bowel Disease: A Cohort Study During the Biologic Era.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- A Case Report and Literature Review of Mesalazine-Induced Kidney Injury in a Pediatric Patient With Ulcerative Colitis.Frontiers in pediatrics · 2022Article
- Renal involvement in children and adolescents with inflammatory bowel disease.Korean journal of pediatrics · 2018Article
- Sulfasalazine induces mitochondrial dysfunction and renal injury.Renal failure · 2017Article
- Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis.Journal of nephropathology · 2017Review
- Chronic tubulointerstitial nephritis induced by 5-aminosalicylate in an ulcerative colitis patient: a rare but serious adverse event.BMJ case reports · 2015Article
- Do gastroenterologists monitor their patients taking 5-amino-salicylates following initiation of treatment.Frontline gastroenterology · 2015Article
- The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease.Clinical journal of the American Society of Nephrology : CJASN · 2014Article
- Mesalazine-induced interstitial nephritis in a patient with ulcerative colitis.BMJ case reports · 2012Article
- Acute interstitial nephritis associated with ulcerative colitis.Clinical and experimental nephrology · 2010Article
- Drug-induced acute interstitial nephritis.Nature reviews. Nephrology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a new case of biopsy-confirmed mesalazine-induced interstitial nephritis in an 18-year-old male with ulcerative colitis. His renal function improved with drug discontinuation and corticosteroid treatment. An English literature review revealed an additional 22 cases of this complication that, taken together, showed (1) a male predominance, (2) an absence of specific symptoms or findings on urinalysis, (3) a 61% frequency of residual chronic renal insufficiency with 13% of patients developing end-stage renal disease, and (4) an apparent favorable response to steroid therapy. We conclude that patients receiving 5-aminosalicylates should be routinely monitored with serum creatinine measurements to prevent this uncommon but potentially serious adverse drug reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.