ArticlePflugers Archiv : European journal of physiology2004
Segment-specific expression of sodium-phosphate cotransporters NaPi-IIa and -IIc and interacting proteins in mouse renal proximal tubules.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Structures of the sodium-coupled phosphate importer SLC34A2 reveal a distinct architecture and gating mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genetic deletion of the kidney sodium/proton exchanger-3 (NHE3) does not alter calcium and phosphate balance due to compensatory responses.Kidney international · 2025Article
- FGF/FGFR signaling in health and disease.Signal transduction and targeted therapy · 2020Review
- PF-06869206 is a selective inhibitor of renal PAmerican journal of physiology. Renal physiology · 2020Article
- Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease.Pflugers Archiv : European journal of physiology · 2020Article
- Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs.International journal of molecular sciences · 2019Article
- Mechanisms of phosphate transport.Nature reviews. Nephrology · 2019Review
- NaPi-IIa interacting partners and their (un)known functional roles.Pflugers Archiv : European journal of physiology · 2019Review
- Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters.Pflugers Archiv : European journal of physiology · 2019Review
- Mechanisms and regulation of epithelial phosphate transport in ruminants: approaches in comparative physiology.Pflugers Archiv : European journal of physiology · 2019Review
- Phosphate imbalance in patients with heart failure.Heart failure reviews · 2017Review
- Effects of phospho- and calciotropic hormones on electrolyte transport in the proximal tubule.F1000Research · 2017Review
- Who regenerates the kidney tubule?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2015Review
- Renal phosphate wasting in the absence of adenylyl cyclase 6.Journal of the American Society of Nephrology : JASN · 2014Article
- Controversies on the origin of proliferating epithelial cells after kidney injury.Pediatric nephrology (Berlin, Germany) · 2014Review
- Differentiated kidney epithelial cells repair injured proximal tubule.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Proximal nephron.Comprehensive Physiology · 2013Review
- Differential modulation of the molecular dynamics of the type IIa and IIc sodium phosphate cotransporters by parathyroid hormone.American journal of physiology. Cell physiology · 2011Article
- Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
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Authors and funding
5 authors.
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Abstract
Sodium-dependent phosphate cotransport in renal proximal tubules (PTs) is heterogeneous with respect to proximal tubular segmentation (S1 vs. S3) and nephron generation (superficial vs. juxtamedullary). In the present study, S1 and S3 segments of superficial and juxtamedullary nephrons were laser-microdissected and mRNA and protein expression of the Na/Pi-cotransporters NaPi-IIa and NaPi-IIc and the PDZ proteins NHERF-1 and PDZK1 determined. Expression of NaPi-IIa mRNA decreased axially in juxtamedullary nephrons. There was no effect of dietary Pi content on NaPi-lla mRNA expression in any proximal tubular segment. The abundance of the NaPi-IIa cotransporter in the brush-border membrane showed inter- and intranephron heterogeneity and increased in response to a low-Pi diet (5 days), suggesting that up-regulation of NaPi-lla occurs via post-transcriptional mechanisms. In contrast, NaPi-IIc mRNA and protein was up-regulated by the low-Pi diet in all nephron generations analysed. NHERF-1 and PDZK1, at both mRNA and protein levels, were distributed evenly along the PTs and did not change after a low-Pi diet.
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