ArticleMolecular psychiatry2004
Multicenter linkage study of schizophrenia loci on chromosome 22q.
Article in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder.Molecular psychiatry · 2006Trial
- Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.Molecular psychiatry · 2005Trial
- The genetic basis of onset age in schizophrenia: evidence and models.Frontiers in genetics · 2023Review
- Vitamin D deficiency, behavioral atypicality, anxiety and depression in children with chromosome 22q11.2 deletion syndrome.Journal of developmental origins of health and disease · 2016Article
- Linkage and Association Analyses of Schizophrenia with Genetic Variations on Chromosome 22q11 in Koreans.Psychiatry investigation · 2016Article
- The Potential Role of Insulin on the Shank-Postsynaptic Platform in Neurodegenerative Diseases Involving Cognition.American journal of Alzheimer's disease and other dementias · 2014Review
- The DAO gene is associated with schizophrenia and interacts with other genes in the Taiwan Han Chinese population.PloS one · 2013Article
- Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.Molecular psychiatry · 2012Article
- Genome-wide association study of multiplex schizophrenia pedigrees.The American journal of psychiatry · 2012Article
- Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.Cell reports · 2012Article
- Schizophrenia: from epidemiology to rehabilitation.Clinical practice and epidemiology in mental health : CP & EMH · 2012Article
- De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms.Molecular psychiatry · 2009Article
- Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia.Molecular psychiatry · 2006Article
- Analyses of the associations between the genes of 22q11 deletion syndrome and schizophrenia.Journal of human genetics · 2006Review
- A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p.American journal of human genetics · 2005Article
- Systematic mutation analysis of KIAA0767 and KIAA1646 in chromosome 22q-linked periodic catatonia.BMC psychiatry · 2005Article
- The importance of modelling heterogeneity in complex disease: application to NIMH Schizophrenia Genetics Initiative data.Human genetics · 2005Article
- Genetic models of schizophrenia and bipolar disorder: overlapping inheritance or discrete genotypes?European archives of psychiatry and clinical neuroscience · 2005Review
Corrections and comments
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Authors and funding
39 authors at 18 institutions in 10 countries.
Funding
Abstract
The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkage analysis even in large samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.