ArticleThe Journal of experimental medicine2004
Pax5 activates immunoglobulin heavy chain V to DJ rearrangement in transgenic thymocytes.
Article in The Journal of experimental medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 31 citations in OpenAlex.
- Misregulation of theFrontiers in immunology · 2018Article
- Transcription factors regulating B cell fate in the germinal centre.Clinical and experimental immunology · 2016Review
- Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.PLoS biology · 2013Article
- Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.The Journal of biological chemistry · 2011Article
- Signaling proteins and transcription factors in normal and malignant early B cell development.Bone marrow research · 2011Article
- Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.The Journal of experimental medicine · 2007Article
- B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages.Experimental cell research · 2007Article
- Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5.Molecular and cellular biology · 2007Article
- B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.Nature immunology · 2004Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice deficient for the B cell-restricted transcription factor Pax5 show a defect in the VH to DJH rearrangement step of immunoglobulin heavy chain gene assembly even though the expression of the V(D)J recombinase is not diminished in Pax5-/- pro-B cells. To investigate whether Pax5 is limiting for VH to DJH rearrangement, we generated transgenic mice which express Pax5 in developing thymocytes. We show that enforced expression of Pax5 in thymocytes results in a partial block in T cell development due to defective pre-TCR signaling in beta-selection. Moreover, our results demonstrate that expression of Pax5 in early thymocytes is sufficient to induce VH to DJH rearrangements in CD4+CD8+ T cells and lead us to suggest that Pax5 may play a direct role in the lineage-specific regulation of immunoglobulin heavy chain gene rearrangement.
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