ArticleThe Journal of cell biology2004
The cohesion protein ORD is required for homologue bias during meiotic recombination.
Article in The Journal of cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 85 citations in OpenAlex.
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.PLoS genetics · 2025Article
- An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes.G3 (Bethesda, Md.) · 2024Article
- Meiotic double-strand break repair DNA synthesis tracts in Arabidopsis thaliana.PLoS genetics · 2024Article
- Building the synaptonemal complex: Molecular interactions between the axis and the central region.PLoS genetics · 2023Review
- Meiotic DNA exchanges inLife science alliance · 2023Article
- Meiotic sister chromatid exchanges are rare in C. elegans.Current biology : CB · 2021Article
- Genetic background impacts the timing of synaptonemal complex breakdown in Drosophila melanogaster.Chromosoma · 2020Article
- Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing.PLoS genetics · 2019Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei.PLoS genetics · 2016Article
- Kdm5/Lid Regulates Chromosome Architecture in Meiotic Prophase I Independently of Its Histone Demethylase Activity.PLoS genetics · 2016Article
- Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation.Current biology : CB · 2016Article
- Holding it together: rapid evolution and positive selection in the synaptonemal complex of Drosophila.BMC evolutionary biology · 2016Article
- Heterochromatin-Associated Proteins HP1a and Piwi Collaborate to Maintain the Association of Achiasmate Homologs in Drosophila Oocytes.Genetics · 2016Article
- Corolla is a novel protein that contributes to the architecture of the synaptonemal complex of Drosophila.Genetics · 2014Article
- Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation.PLoS genetics · 2014Article
- The cohesin subunit Rad21 is required for synaptonemal complex maintenance, but not sister chromatid cohesion, during Drosophila female meiosis.PLoS genetics · 2014Article
- Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Meiotic development in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
During meiosis, sister chromatid cohesion is required for normal levels of homologous recombination, although how cohesion regulates exchange is not understood. Null mutations in orientation disruptor (ord) ablate arm and centromeric cohesion during Drosophila meiosis and severely reduce homologous crossovers in mutant oocytes. We show that ORD protein localizes along oocyte chromosomes during the stages in which recombination occurs. Although synaptonemal complex (SC) components initially associate with synapsed homologues in ord mutants, their localization is severely disrupted during pachytene progression, and normal tripartite SC is not visible by electron microscopy. In ord germaria, meiotic double strand breaks appear and disappear with frequency and timing indistinguishable from wild type. However, Ring chromosome recovery is dramatically reduced in ord oocytes compared with wild type, which is consistent with the model that defects in meiotic cohesion remove the constraints that normally limit recombination between sisters. We conclude that ORD activity suppresses sister chromatid exchange and stimulates inter-homologue crossovers, thereby promoting homologue bias during meiotic recombination in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.