Evidence map›Paper›PMID 15007010›Full record

Trial reportCirculation2004

Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial.

Rainer Hambrecht, Claudia Walther, Sven Möbius-Winkler, Stephan Gielen, Axel Linke, Katrin Conradi, Sandra Erbs, Regine Kluge, Kai Kendziorra, Osama Sabri and 2 more

5 registry-linked trialsAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Circulation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 155 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 16 pooled it
41.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02910154 nacompletedstarted 2016, after this paper: background citation

Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower Cohort

Ran2016Enrolled62Registered outcomes9Posted comparisons0ConditionsAngina Pectoris, Coronary Microvascular DiseaseArmsdiet, Medication (with statin and ACE-inhibition), training
PMID 19878986PMID 23432189PMID 10675425PMID 11788217PMID 11991214PMID 12147179PMID 12914662PMID 13394341PMID 15020531PMID 15671433PMID 16368303PMID 16458167other papers from this trial
Open the trial in the graph
NCT00825604 phase2withdrawnnot on this mapstarted 2009, after this paper: background citation

Quality of Life and Achievement of Target of Treatment After Optimized Medical Treatment, Physical Training and Smoking Cessation With or Without Percutaneous Coronary Intervention in Patients With Stable Angina Pectoris.

TypeinterventionalSponsorGöteborg UniversityRan2009 to 2010Enrolled0ConditionsStable Angina PectorisArmsPercutaneous coronary angioplasty (PCI)
NCT01551927 completednot on this mapstarted 2011, after this paper: background citation

What Are the Expectations for Future Examination and Treatment in Patients Undergoing Evaluation and Treatment of Coronary Heart Disease?

TypeobservationalSponsorGöteborg UniversityRan2011 to 2014Enrolled754ConditionsCoronary Heart Disease
NCT03669211 nacompletednot on this mapstarted 2019, after this paper: background citation

A Pilot, Prospective Study Assessing the Evolution of Cardiovascular Function and Quality of Life in Patients With Acute Coronary Syndrome, Included in the SCArabée Therapeutic Education Program

TypeinterventionalSponsorGroupe Hospitalier Mutualiste de GrenobleRan2019 to 2020Enrolled30ConditionsAcute Coronary SyndromeArmsCardiac stress test
NCT07182955 narecruitingnot on this mapstarted 2025, after this paper: background citation

Determinants of Cardiorespiratory Fitness and Effects of High Intensity Interval Training (HIIT) in Patients With Angina and No Obstructive Coronary Artery Disease (ANOCA)

TypeinterventionalSponsorUniversity of VirginiaRan2025 to 2026Enrolled25ConditionsMINOCA, Shortness of Breath, Atherosclerotic Heart Disease of Native Coronary ArteryArmsEXERCISE TRAINING WITH OR WITHOUT MEDICATION
3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 16 syntheses or guidelines pooled it, 771 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Exercise-based cardiac rehabilitation for coronary heart disease.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Exercise-based cardiac rehabilitation for adults with stable angina.The Cochrane database of systematic reviews · 2018
    Pooled it
  9. Guideline
  10. Exercise-based cardiac rehabilitation for coronary heart disease.The Cochrane database of systematic reviews · 2016
    Pooled it
  11. Pooled it
  12. Guideline
  13. Pooled it
  14. Guideline
  15. Guideline
  16. Pooled it
  17. Trial
  18. Trial
  19. Trial
  20. Trial

95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rainer HambrechtUniversität Leipzig, Herzzentrum GmbH, Klinik für Innere Medizin/Kardiologie, Leipzig, Germany. hamr@medizin.uni-leipzig.de
Claudia Walther
Sven Möbius-Winkler
Stephan Gielen
Axel Linke
Katrin Conradi
Sandra Erbs
Regine Kluge
Kai Kendziorra
Osama Sabri
Peter Sick
Gerhard Schuler
Klinik und Poliklinik für Nuklearmedizin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRegular exercise in patients with stable coronary artery disease has been shown to improve myocardial perfusion and to retard disease progression. We therefore conducted a randomized study to compare the effects of exercise training versus standard percutaneous coronary intervention (PCI) with stenting on clinical symptoms, angina-free exercise capacity, myocardial perfusion, cost-effectiveness, and frequency of a combined clinical end point (death of cardiac cause, stroke, CABG, angioplasty, acute myocardial infarction, and worsening angina with objective evidence resulting in hospitalization). METHODS AND

resultsA total of 101 male patients aged < or =70 years were recruited after routine coronary angiography and randomized to 12 months of exercise training (20 minutes of bicycle ergometry per day) or to PCI. Cost efficiency was calculated as the average expense (in US dollars) needed to improve the Canadian Cardiovascular Society class by 1 class. Exercise training was associated with a higher event-free survival (88% versus 70% in the PCI group, P=0.023) and increased maximal oxygen uptake (+16%, from 22.7+/-0.7 to 26.2+/-0.8 mL O2/kg, P<0.001 versus baseline, P<0.001 versus PCI group after 12 months). To gain 1 Canadian Cardiovascular Society class, 6956 dollars was spent in the PCI group versus 3429 dollars in the training group (P<0.001).

conclusionsCompared with PCI, a 12-month program of regular physical exercise in selected patients with stable coronary artery disease resulted in superior event-free survival and exercise capacity at lower costs, notably owing to reduced rehospitalizations and repeat revascularizations.

Indexed as

Angioplasty, Balloon, CoronaryExercise TherapyAgedCardiac CatheterizationCoronary DiseaseDisease-Free SurvivalExercise TestHospitalizationHumansMaleMiddle AgedOrganophosphorus CompoundsOrganotechnetium CompoundsOxygen ConsumptionRadionuclide ImagingRadiopharmaceuticalsOrganophosphorus CompoundsOrganotechnetium CompoundsRadiopharmaceuticalstechnetium tc-99m tetrofosmin

Identifiers

PMID15007010
OpenAlexW2125702693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.