ArticleBMC neuroscience2004
Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila.
Article in BMC neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Evidence thatbioRxiv : the preprint server for biology · 2025Article
- The brain atlas of a subsocial bee reflects that of eusocial Hymenoptera.Genes, brain, and behavior · 2024Article
- Perception of Daily Time: Insights from the Fruit Flies.Insects · 2021Review
- Article
- High-Frequency Neuronal Bursting is Essential for Circadian and Sleep Behaviors inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Article
- The Effect of General Anaesthesia on Circadian Rhythms in Behaviour and Clock Gene Expression ofClocks & sleep · 2020Article
- Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster.PLoS genetics · 2019Article
- Control of Sleep Onset by Shal/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- A new promoter element associated with daily time keeping in Drosophila.Nucleic acids research · 2017Article
- Circadian Rhythms and Sleep inGenetics · 2017Review
- Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.Genes & development · 2016Article
- Evolutionary divergence of core and post-translational circadian clock genes in the pitcher-plant mosquito, Wyeomyia smithii.BMC genomics · 2015Article
- Oxidative Stress and Maxi Calcium-Activated Potassium (BK) Channels.Biomolecules · 2015Review
- A Transcriptomic Analysis of Cave, Surface, and Hybrid Isopod Crustaceans of the Species Asellus aquaticus.PloS one · 2015Article
- Article
- Regulation of insect behavior via the insulin-signaling pathway.Frontiers in physiology · 2013Review
- Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Interaction between sleep and metabolism in Drosophila with altered octopamine signaling.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSLOB binds to and modulates the activity of the Drosophila Slowpoke (dSlo) calcium activated potassium channel. Recent microarray analyses demonstrated circadian cycling of slob mRNA.
resultsWe report the mRNA and protein expression pattern of slob in Drosophila heads. slob transcript is present in the photoreceptors, optic lobe, pars intercerebralis (PI) neurons and surrounding brain cortex. SLOB protein exhibits a similar distribution pattern, and we show that it cycles in Drosophila heads, in photoreceptor cells and in neurosecretory cells of the PI. The cycling of SLOB is altered in various clock gene mutants, and SLOB is expressed in ectopic locations in tim01 flies. We also demonstrate that SLOB no longer cycles in the PI neurons of Clkjrk flies, and that SLOB expression is reduced in the PI neurons of flies that lack pigment dispersing factor (PDF), a neuropeptide secreted by clock cells.
conclusionsThese data are consistent with the idea that SLOB may participate in one or more circadian pathways in Drosophila.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.