ReviewInternational journal of hematology2004
Progress in the understanding of the protein C anticoagulant pathway.
Review in International journal of hematology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 107 citations in OpenAlex.
- Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay.Journal of thrombosis and thrombolysis · 2011Trial
- Hematological abnormalities in liver cirrhosis.World journal of hepatology · 2024Review
- The Challenge of Anticoagulation in Liver Cirrhosis.Visceral medicine · 2024Review
- Effects of body composition on the procoagulant imbalance in obese patients.Journal of thrombosis and thrombolysis · 2021Article
- Anticoagulation in the cirrhotic patient.JHEP reports : innovation in hepatology · 2019Review
- The imbalance of procoagulant and anticoagulant factors in patients with chronic liver diseases in North India.Blood research · 2017Article
- Coagulopathy in liver disease: Lack of an assessment tool.World journal of gastroenterology · 2015Review
- Thrombin generation in plasma from patients with cirrhosis supplemented with normal plasma: considerations on the efficacy of treatment with fresh-frozen plasma.Internal and emergency medicine · 2012Article
- The beneficial effect of direct peritoneal resuscitation on septic shock in rats.Journal of biomedicine & biotechnology · 2011Article
- Effects of inhalable particulate matter on blood coagulation.Journal of thrombosis and haemostasis : JTH · 2010Article
- The cost-benefit ratio of screening pregnant women for thrombophilia.Blood transfusion = Trasfusione del sangue · 2007Article
- Genetic risk factors for deep vein thrombosis among Japanese: importance of protein S K196E mutation.International journal of hematology · 2006Review
- Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities.The Journal of clinical investigation · 2005Article
- Candidate-based proteomics in the search for biomarkers of cardiovascular disease.The Journal of physiology · 2005Review
- Strategies to avoid empiric blood product administration in liver transplant surgery.Saudi journal of anaesthesiaReview
- Liver fibrosis severity evaluated by shear-wave elastography is associated with procoagulant and systemic inflammatory activity in patients with cirrhosis.Annals of gastroenterologyArticle
- The safety of ultrasound guided central venous cannulation in patients with liver disease.Saudi journal of anaesthesiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A natural anticoagulant pathway denoted the protein C system provides specific and efficient control of blood coagulation. Protein C is the key component of the system and circulates in the blood as a zymogen to an anticoagulant serine protease. Activation of protein C is achieved on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor stimulates the activation of protein C on the endothelium. Activated protein C (APC) modulates blood coagulation by cleaving a limited number of peptide bonds in factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively. Vitamin K-dependent protein S stimulates the APC-mediated regulation of coagulation. Not only is protein S involved in the degradation of FVIIIa, but so is FV, which in recent years has been found to be a Janus-faced protein with both procoagulant and anticoagulant potentials. A number of genetic defects affecting the anticoagulant function of the protein C system, eg, APC resistance (Arg506Gln or FV Leiden) and deficiencies of protein C and protein S constitute major risk factors of venous thrombosis. The protein C system also has anti-inflammatory and antiapoptotic potentials, the molecular mechanisms of which are beginning to be unraveled. APC has emerged in recent years as a useful therapeutic compound in the treatment of severe septic shock. The beneficial effect of APC is believed be due to both its anticoagulant and its anti-inflammatory properties.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.