ArticleJournal of clinical microbiology1992
Retrospective evaluation of two latex agglutination tests for detection of circulating antigens during invasive candidosis.
Article in Journal of clinical microbiology, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. British Society for Medical Mycology.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Guideline
- Enolase antigen, mannan antigen, Cand-Tec antigen, and beta-glucan in patients with candidemia.Journal of clinical microbiology · 1996Trial
- Plasma (1-->3)-beta-D-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis.Journal of clinical microbiology · 1995Trial
- The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia.Critical care (London, England) · 2010Review
- New approach for diagnosis of candidemia based on detection of a 65-kilodalton antigen.Clinical and vaccine immunology : CVI · 2009Article
- [Serological tests for diagnosing fungal infections].Wiener medizinische Wochenschrift (1946) · 2007Article
- Increased sensitivity of mannanemia detection tests by joint detection of alpha- and beta-linked oligomannosides during experimental and human systemic candidiasis.Journal of clinical microbiology · 2004Article
- Current status of nonculture methods for diagnosis of invasive fungal infections.Clinical microbiology reviews · 2002Review
- Simple and rapid detection of Candida albicans DNA in serum by PCR for diagnosis of invasive candidiasis.Journal of clinical microbiology · 2000Article
- Use of monoclonal antibody in diagnosis of candidiasis caused by Candida albicans: detection of circulating aspartyl proteinase antigen.Clinical and diagnostic laboratory immunology · 1999Article
- New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis.Journal of clinical microbiology · 1999Article
- PCR detection of DNA specific for Trichosporon species in serum of patients with disseminated trichosporonosis.Journal of clinical microbiology · 1999Article
- Serologic response to cell wall mannoproteins and proteins of Candida albicans.Clinical microbiology reviews · 1998Review
- Detection of antibodies to Candida albicans germ tubes for diagnosis and therapeutic monitoring of invasive candidiasis in patients with hematologic malignancies.Journal of clinical microbiology · 1997Article
- Semiquantitative polymerase chain reaction enzyme immunoassay for diagnosis of disseminated candidiasis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Clearances of Candida albicans-derived alpha- and beta-linked mannose residues in sera from patients with candidiasis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Clinical and laboratory diagnosis of invasive candida infection in neutropenic patients.Medical oncology (Northwood, London, England) · 1996Review
- Diagnostic value of anti-Candida enolase antibodies.Journal of clinical microbiology · 1994Article
- Nonculture methods for diagnosis of disseminated candidiasis.Clinical microbiology reviews · 1993Review
- Circulating Candida antigens and antibodies: useful markers of candidemia.Journal of clinical microbiology · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two latex agglutination tests for the detection of Candida antigens, Pastorex Candida (Sanofi Diagnostics Pasteur, Marnes-la-Coquette, France) and Cand-Tec (Ramco Laboratories, Inc., Houston, Tex.), were applied to 79 serum samples from 19 patients who were retrospectively selected on the basis of mycological and clinical evidence of C. albicans infection and the availability of serial serum samples taken near the date of a positive culture. The specificity in 60 control individuals was 100% for Pastorex and 98.3% for Cand-Tec. The tests scored positive for 10 (52.6%) and 9 (47.4%) patients, respectively. Pastorex detected antigen in only 3 of 12 patients (25%) with positive antibody detection tests, but was positive for all 7 patients (100%) who produced no or a low antibody response, suggesting that the test performs better in the absence of antibodies. However, the sensitivity of Pastorex also increased with the number of samples available per patient, which was lower for high-antibody-responder patients (2.8 versus 5.7). If the patients who provided only one or two serum samples were eliminated, the sensitivity of Pastorex rose to 76.9%. For the Cand-Tec, the sensitivity was not related to the presence of antibodies, nor was it related to the number of samples per patient. The observed antigenemia was transient with both Pastorex and Cand-Tec. Only 12.5% of the positive reactions occurred on the same serum sample, confirming that the two tests react with different antigens. A positive antigen test preceded other diagnostic indications for 6 of 10 Pastorex-positive patients and 5 of 9 Cand-Tec-positive patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.