ArticleHuman genetics2004
Association between IFNA genotype and the risk of sarcoidosis.
Article in Human genetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis.Frontiers in public health · 2024Pooled it
- Increased serum interferon activity in sarcoidosis compared to that in tuberculosis: Implication for diagnosis?Heliyon · 2024Article
- Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study.Archives of rheumatology · 2023Article
- Article
- The Immunogenetics of Granulomatous Diseases.Advances in experimental medicine and biology · 2022Article
- Plasmacytoid dendritic cells in cutaneous sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Familial sarcoidosis: Report of a mother and her son.European journal of rheumatology · 2017Article
- The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis.PloS one · 2017Article
- Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches.Clinics in chest medicine · 2015Review
- Revealing mammalian evolutionary relationships by comparative analysis of gene clusters.Genome biology and evolution · 2012Article
- Peripheral blood gene expression as a novel genomic biomarker in complicated sarcoidosis.PloS one · 2012Article
- Influence of genetic variants in type I interferon genes on melanoma survival and therapy.PloS one · 2012Article
- Conversion events in gene clusters.BMC evolutionary biology · 2011Article
- Interferon-alpha Induced Sarcoidosis with Cutaneous Involvement along the Lines of Venous Drainage.Annals of dermatology · 2011Article
- The potential of the immunological markers of sarcoidosis in exhaled breath and peripheral blood as future diagnostic and monitoring techniques.Inflammopharmacology · 2011Review
- Tuberculosis as a complex trait: impact of genetic epidemiological study design.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Genetic epidemiology of tuberculosis susceptibility: impact of study design.PLoS pathogens · 2011Review
- Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.BMC infectious diseases · 2010Article
- Dendritic cells in the pathogenesis of sarcoidosis.American journal of respiratory cell and molecular biology · 2010Review
- Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.American journal of respiratory and critical care medicine · 2009Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sarcoidosis is known to be a systemic granulomatous disorder characterized by a cell-mediated Th1-type inflammatory response. To identify a key genetic factor in the pathogenesis of sarcoidosis, we investigated single nucleotide polymorphisms within 10 candidate genes involved in type 1 immune process ( IFNA17, IFNB, IFNG, IFNGR1, IFNGR2, IL12B, IL12RB1, IL12RB2, ETA-1, and NRAMP1) in an association-based study of 102 Japanese patients with sarcoidosis, 114 with tuberculosis, and 110 control subjects. After correction for multiple testing, an IFNA17 polymorphism (551T-->G) was found to be associated with susceptibility to sarcoidosis (odds ratio 3.27 [95% CI: 1.44-7.46], P=0.004, P(c)=0.04), but not to tuberculosis. We observed no significant associations with the other polymorphisms of the Th1-related genes. We further typed another IFNA polymorphism ( IFNA10 60T-->A) and confirmed two major haplotypes of the IFNA gene, viz., allele 1: IFNA10 [60T]- IFNA17 [551T] and allele 2: IFNA10 [60A]- IFNA17 [551G], in the Japanese population. In healthy subjects, IFNA allele 2, which is over-represented in patients with sarcoidosis, was significantly associated with increased IFN-alpha and IL-12p70 production induced by Sendai virus in vitro. This study suggests that possession of the IFNA allele with higher levels of IFN-alpha significantly increases the risk of sarcoidosis.
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