ReviewCellular and molecular life sciences : CMLS2004
Protein NMR in biomedical research.
Review in Cellular and molecular life sciences : CMLS, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Metabolic Profile of Senegalese Sole (Molecules (Basel, Switzerland) · 2025Article
- Resolving Hidden Solution Conformations of Hemoglobin Using IMS-IMS on a Cyclic Instrument.Journal of the American Society for Mass Spectrometry · 2023Article
- N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.Antimicrobial agents and chemotherapy · 2017Article
- Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Immunological reviews · 2015Review
- High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.Current topics in medicinal chemistry · 2015Review
- NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.Chemical reviews · 2014Review
- Two-point magnitude MRI for rapid mapping of brown adipose tissue and its application to the R6/2 mouse model of Huntington disease.PloS one · 2014Article
- NMR analysis reveals 17β-estradiol induced conformational change in ERβ ligand binding domain expressed in E. coli.Molecular biology reports · 2011Article
- A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.Molecular immunology · 2011Article
- Article
- High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands.Journal of pharmaceutical sciences · 2008Review
- Perspectives of biomolecular NMR in drug discovery: the blessing and curse of versatility.Journal of biomolecular NMR · 2007Article
- A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase.Glycoconjugate journal · 2006Article
- Determining the optimal size of small molecule mixtures for high throughput NMR screening.Journal of biomolecular NMR · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a versatile biophysical technique with wide applicability in drug discovery research, particularly for the detection and characterization of molecular interactions. This review highlights in a comprehensive manner the aspects of biomolecular NMR which are most beneficial for pharmaceutical research and presents them as contributions to the different stages of a drug discovery program: target selection, assay development, lead generation and lead optimization. Emphasis is put on the concept of the particular NMR application, rather than on technical details, and on recent examples. Finally, an appendix of frequently asked questions is given.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.