ReviewApoptosis : an international journal on programmed cell death2004
The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling.
Review in Apoptosis : an international journal on programmed cell death, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 81 citations in OpenAlex.
- Endogenous Expression of HSP70 and Thioredoxin-1 During Methamphetamine-Induced Degeneration.Biomedicines · 2026Article
- Adenosine A1 Receptor Agonist (R-PIA) before Pilocarpine Modulates Pro- and Anti-Apoptotic Factors in an Animal Model of Epilepsy.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Preconditioning the uterine unfolded protein response maintains non-apoptotic Caspase 3-dependent quiescence during pregnancy.Cell death & disease · 2018Article
- IMMUNEPOTENT CRP induces cell cycle arrest and caspase-independent regulated cell death in HeLa cells through reactive oxygen species production.BMC cancer · 2018Article
- Different BCR/Abl protein suppression patterns as a converging trait of chronic myeloid leukemia cell adaptation to energy restriction.Oncotarget · 2016Article
- MST1/MST2 Protein Kinases: Regulation and Physiologic Roles.Biochemistry · 2016Review
- Repeated Estradiol Treatment Attenuates Chronic Cerebral Hypoperfusion-Induced Neurodegeneration in Rat Hippocampus.Cellular and molecular neurobiology · 2016Article
- Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid.Journal of biomedical science · 2013Article
- Alteration of isocitrate dehydrogenase following acute ischemic injury as a means to improve cellular energetic status in neuroadaptation.CNS & neurological disorders drug targets · 2013Article
- Caspase activation contributes to astrogliosis.Brain research · 2012Article
- The role of central nervous system development in late-onset neurodegenerative disorders.Developmental neuroscience · 2012Review
- Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.Glia · 2011Article
- Fas-associated factor 1 as a regulator of olfactory axon guidance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Pathological accumulation of atrophin-1 in dentatorubralpallidoluysian atrophy.International journal of clinical and experimental pathology · 2011Review
- Combination of intracortically administered VEGF and environmental enrichment enhances brain protection in developing rats.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Essential role of the redox-sensitive kinase p66shc in determining energetic and oxidative status and cell fate in neuronal preconditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Regional and temporal profiles of calpain and caspase-3 activities in postnatal rat brain following repeated propofol administration.Developmental neuroscience · 2010Article
- Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology.Schizophrenia bulletin · 2009Review
- Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.Journal of neuropathology and experimental neurology · 2009Article
- HIV-1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology.Glia · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Caspases are a family of cysteine proteases that are expressed as inactive zymogens and undergo proteolytic maturation in a sequential manner in which initiator caspases cleave and activate the effector caspases 3, 6 and 7. Effector caspases cleave structural proteins, signaling molecules, DNA repair enzymes and proteins which inhibit apoptosis. Activation of effector, or executioner, caspases has historically been viewed as a terminal event in the process of programmed cell death. Emerging evidence now suggests a broader role for activated caspases in cellular maturation, differentiation and other non-lethal events. The importance of activated caspases in normal cell development and signaling has recently been extended to the CNS where these proteases have been shown to contribute to axon guidance, synaptic plasticity and neuroprotection. This review will focus on the adaptive roles activated caspases in maintaining viability, the mechanisms by which caspases are held in check so as not produce apoptotic cell death and the ramifications of these observations in the treatment of neurological disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.