ArticleMolecular biology of the cell2004
Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 127 citations in OpenAlex.
- Atg23 Interacts With Both the N- and C-termini of Atg9 Via a Hydrophobic Binding Pocket.bioRxiv : the preprint server for biology · 2025Article
- In vivo localization of iron starvation induced proteins under variable iron supplementation regimes inPlant direct · 2022Article
- Autophagy-Associated IL-15 Production Is Involved in the Pathogenesis of Leprosy Type 1 Reaction.Cells · 2021Article
- Structure of human ATG9A: how holey art thou?Autophagy · 2020Article
- Gyp1 has a dual function as Ypt1 GAP and interaction partner of Atg8 in selective autophagy.Autophagy · 2019Article
- Article
- The ULK1-FBXW5-SEC23B nexus controls autophagy.eLife · 2018Article
- Noncanonical autophagy at ER exit sites regulates procollagen turnover.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Autophagy in the context of the cellular membrane-trafficking system: the enigma of Atg9 vesicles.Biochemical Society transactions · 2017Review
- The coordination of membrane fission and fusion at the end of autophagosome maturation.Current opinion in cell biology · 2017Review
- Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles.Nature communications · 2016Article
- An overview of macroautophagy in yeast.Journal of molecular biology · 2016Review
- Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation.Autophagy · 2016Article
- The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation.eLife · 2015Article
- ER exit sites are physical and functional core autophagosome biogenesis components.Molecular biology of the cell · 2013Article
- Review
- A trapper keeper for TRAPP, its structures and functions.Cellular and molecular life sciences : CMLS · 2012Review
- Modulating macroautophagy: a neuronal perspective.Future medicinal chemistry · 2012Review
- A methodology for detecting the orthology signal in a PPI network at a functional complex level.BMC bioinformatics · 2012Article
- Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.Molecular biology of the cell · 2012Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Cvt pathway is a biosynthetic transport route for a distinct subset of resident yeast vacuolar hydrolases, whereas macroautophagy is a nonspecific degradative mechanism that allows cell survival during starvation. Yet, these two vacuolar trafficking pathways share a number of identical molecular components and are morphologically very similar. For example, one of the hallmarks of both pathways is the formation of double-membrane cytosolic vesicles that sequester cargo before vacuolar delivery. The origin of the vesicle membrane has been controversial and various lines of evidence have implicated essentially all compartments of the endomembrane system. Despite the analogies between the Cvt pathway and autophagy, earlier work has suggested that the origin of the engulfing vesicle membranes is different; the endoplasmic reticulum is proposed to be required only for autophagy. In contrast, in this study we demonstrate that the endoplasmic reticulum and/or Golgi complex, but not endosomal compartments, play an important role for both yeast transport routes. Along these lines, we demonstrate that Berkeley bodies, a structure generated from the Golgi complex in sec7 cells, are immunolabeled with Atg8, a structural component of autophagosomes. Finally, we also show that none of the yeast t-SNAREs are located at the preautophagosomal structure, the presumed site of double-membrane vesicle formation. Based on our results, we propose two models for Cvt vesicle biogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.