ArticleMolecular biology of the cell2004
Listeria monocytogenes actin-based motility varies depending on subcellular location: a kinematic probe for cytoarchitecture.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Partitioning of ribonucleoprotein complexes from the cellular actin cortex.Science advances · 2022Article
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- Stathmin recruits tubulin to Listeria monocytogenes-induced actin comets and promotes bacterial dissemination.Cellular and molecular life sciences : CMLS · 2019Article
- Article
- Internetwork competition for monomers governs actin cytoskeleton organization.Nature reviews. Molecular cell biology · 2016Article
- An experimental and computational study of the effect of ActA polarity on the speed of Listeria monocytogenes actin-based motility.PLoS computational biology · 2009Article
- Curvature and torsion in growing actin networks.Physical biology · 2008Article
- The SPI-2 type III secretion system restricts motility of Salmonella-containing vacuoles.Cellular microbiology · 2007Article
- Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility.The Journal of cell biology · 2007Article
- Emergence of large-scale cell morphology and movement from local actin filament growth dynamics.PLoS biology · 2007Article
- Early endosomes associated with dynamic F-actin structures are required for late trafficking of H. pylori VacA toxin.The Journal of cell biology · 2007Article
- Bacterial shape and ActA distribution affect initiation of Listeria monocytogenes actin-based motility.Biophysical journal · 2005Article
- Large-scale quantitative analysis of sources of variation in the actin polymerization-based movement of Listeria monocytogenes.Biophysical journal · 2005Article
- Pleiotropic enhancement of bacterial pathogenesis resulting from the constitutive activation of the Listeria monocytogenes regulatory factor PrfA.Infection and immunity · 2005Article
- Biophysical parameters influence actin-based movement, trajectory, and initiation in a cell-free system.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intracellular Listeria monocytogenes actin-based motility is characterized by significant individual variability, which can be influenced by cytoarchitecture. L. monocytogenes was used as a probe to transmit information about structural variation among subcellular domains defined by mitochondrial density. By analyzing the movement of a large population of L. monocytogenes in PtK2 cells, we found that mean speed and trajectory curvature were significantly larger for bacteria moving in mitochondria-containing domains (generally perinuclear) than for bacteria moving in mitochondria-free domains (generally peripheral). Analysis of bacteria that traversed both mitochondria-containing and mitochondria-free domains revealed that these motile differences were not intrinsic to bacteria themselves. Disruption of mitochondrial respiration did not affect bacterial mean speed, speed persistence, or trajectory curvature. In contrast, microtubule depolymerization lead to decreased mean speed per bacterium and increased mean speed persistence of L. monocytogenes moving in mitochondria-free domains compared with untreated cells. L. monocytogenes were also observed to physically collide with mitochondria and push them away from the bacterial path of motion, causing bacteria to slow down before rapidly resuming their speed. Our results show that subcellular domains along with microtubule depolymerization may influence the actin cytoskeleton to affect L. monocytogenes speed, speed persistence, and trajectory curvature.
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