ArticleInfection and immunity1992
Effects of cytokines, complement, and antibody on the neutrophil respiratory burst and phagocytic response to Plasmodium falciparum merozoites.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- Cellular and molecular interactions underlying the peripheral immune responses to blood-stage malaria infections.ImmunoHorizons · 2026Review
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- Neutrophils impose strong immune pressure against PfEMP1 variants implicated in cerebral malaria.EMBO reports · 2022Article
- Improvement of the antibody-dependent respiratory burst assay for assessing protective immune responses to malaria.Open biology · 2022Article
- Review
- Complement in malaria immunity and vaccines.Immunological reviews · 2020Review
- A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates.Nature communications · 2019Article
- Recent insights into humoral immunity targeting Plasmodium falciparum and Plasmodium vivax malaria.International journal for parasitology · 2017Review
- Antibodies to Plasmodium falciparum merozoite surface protein-1p19 malaria vaccine candidate induce antibody-dependent respiratory burst in human neutrophils.Malaria journal · 2015Article
- Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum.Journal of leukocyte biology · 2014Article
- Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- The complexities of malaria disease manifestations with a focus on asymptomatic malaria.Malaria journal · 2012Review
- The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.PloS one · 2012Article
- Article
- Article
- Elevated levels of IL-10 and G-CSF associated with asymptomatic malaria in pregnant women.Infectious diseases in obstetrics and gynecology · 2010Article
- Inhibition of erythrocyte invasion and Plasmodium falciparum merozoite surface protein 1 processing by human immunoglobulin G1 (IgG1) and IgG3 antibodies.Infection and immunity · 2009Article
- Fc-receptors and immunity to malaria: from models to vaccines.Parasite immunology · 2009Review
- The importance of human FcgammaRI in mediating protection to malaria.PLoS pathogens · 2007Article
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction between Plasmodium falciparum merozoites and human neutrophils, as well as the role of cytokines, complement, and antimalarial antibody on this interaction, was examined in vitro by measuring luminol-dependent chemiluminescence and phagocytosis. Merozoites, in the presence of heat-inactivated (56 degrees C/30 min) normal serum, had very little effect on the neutrophil chemiluminescence. This response was significantly enhanced by the addition of normal serum (containing normal complement activity). In the presence of serum or plasma containing anti-P. falciparum antibodies (IS) with no detectable complement activity, the merozoites induced a marked response characterized by an increase in initial peak rate of chemiluminescence and a sustained increased rate of chemiluminescence. However, this response was not further increased if IS containing complement activity was used. Pretreatment of neutrophils with either tumor necrosis factor alpha, lymphotoxin, or gamma interferon significantly increased the neutrophil response to IS-treated merozoites, reflected in an increased initial peak rate and sustained increased rate of chemiluminescence. The effects of cytokine treatment of neutrophils and IS opsonization of merozoites were synergistic. In association with the changes in the chemiluminescence responses, IS was shown to promote phagocytosis of merozoites by neutrophils, and this event was further increased by treating neutrophils with the cytokines. The results emphasize the importance of antibody and cytokines in neutrophil-mediated damage of P. falciparum merozoites.
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