Evidence map›Paper›PMID 15001815›Full record

ReviewNeuromolecular medicine2004

Genes associated with addiction: alcoholism, opiate, and cocaine addiction.

Mary Jeanne Kreek, David A Nielsen, K Steven LaForge

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuromolecular medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 149 citations in OpenAlex.

  1. Trial
  2. Article
  3. Genetic and Epigenetic Approaches to Opioid Use Disorder.Expert reviews in molecular medicine · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Analysis of the Methylation Level of theInternational journal of molecular sciences · 2023
    Article
  8. DNA Methylation of the Dopamine TransporterInternational journal of molecular sciences · 2023
    Article
  9. Methylation in the Promoter Region of the Dopamine TransporterInternational journal of environmental research and public health · 2022
    Article
  10. Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  11. Article
  12. Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021
    Review
  13. Review
  14. The Gut Microbiome and Substance Use Disorder.Frontiers in neuroscience · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review.International journal of molecular sciences · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mary Jeanne KreekLaboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. kreek@rockefeller.edu
David A Nielsen
K Steven LaForge
Rockefeller University · US

Funding

WOUND HEALING IN INDIVIDUALS OF DIFFERENT AGE AND GENETIC BACKGROUNDM01RR000102 · NCRR · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 1985 to 2006
$32.8M
ULTRASTUCTURE, RECEPTORS, AND GENE EXPRESSIONP60DA005130 · NIDA · ROCKEFELLER UNIVERSITY · PI KREEK, MARY J · 2002 to 2012
$30.6M
ADDICTIONS: GENOTYPES, POLYMOPHISMS, AND FUNCTIONR01DA012848 · NIDA · ROCKEFELLER UNIVERSITY · PI KREEK, MARY J · 1999 to 2003
$4.5M
MU OPIOID RECEPTOR GENE IN HEROIN ADDICTSR01DA009444 · NIDA · UNIVERSITY OF CINCINNATI · PI YU, LEI · 1994 to 2003
$1.5M
Addictive Drugs-Pharmacology &PhysiologyK05DA000049 · NIDA · ROCKEFELLER UNIVERSITY · PI KREEK, MARY J · 1985 to 2007
$1.0M
NCRR NIH HHS M01-RR00102NIDA NIH HHS K05-DA00049NIDA NIH HHS P60-DA05130NIDA NIH HHS R01-DA09444NIDA NIH HHS R01-DA12848
6 · The paper itself

Abstract

Drug addiction is a complex disorder that has a large spectrum of causes. Vulnerability to addiction has been shown in twin studies to have a robust genetic component. This genetic basis for addiction has general and specific components for each drug abused. Although many genes have been implicated in drug addiction, only a handful have either been replicated to have an association or to have an identified functional mechanism related to specific effects of abused drugs. A few selected genetic variants that currently look promising for the study of alcohol, opiate, and cocaine addiction are discussed in this article.

Indexed as

AlcoholismAnimalsBrain ChemistryCocaine-Related DisordersGenetic Predisposition to DiseaseGenotypeHumansOpioid-Related DisordersPolymorphism, GeneticSubstance-Related Disorders

Identifiers

PMID15001815
OpenAlexW2028836273

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.