ArticleInfection and immunity1992
Experimental model of intracerebral infection with Cryptococcus neoformans: roles of phagocytes and opsonization.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Article
- DoesFuture microbiology · 2025Article
- Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo.Journal of neuroinflammation · 2025Article
- Article
- Preclinical Models for Cryptococcosis of the CNS and Their Characterization Using In Vivo Imaging Techniques.Journal of fungi (Basel, Switzerland) · 2024Review
- Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.PLoS neglected tropical diseases · 2023Article
- Innate Immune Responses toJournal of fungi (Basel, Switzerland) · 2017Article
- Review
- Traffic of leukocytes and cytokine up-regulation in the central nervous system in a murine model of neuroparacoccidioidomycosis.Mycopathologia · 2013Article
- Pathogenesis of pulmonary Cryptococcus gattii infection: a rat model.Mycopathologia · 2010Article
- IL-4/IL-13-dependent alternative activation of macrophages but not microglial cells is associated with uncontrolled cerebral cryptococcosis.The American journal of pathology · 2009Article
- Animal models of Streptococcus pneumoniae disease.Clinical microbiology reviews · 2008Review
- Animal models: an important tool in mycology.Medical mycology · 2007Review
- Method for inducing experimental pneumococcal meningitis in outbred mice.BMC microbiology · 2004Article
- Cytokine and inducible nitric oxide synthase mRNA expression during experimental murine cryptococcal meningoencephalitis.Infection and immunity · 2004Article
- Enhanced resistance to Cryptococcus neoformans infection induced by chloroquine in a murine model of meningoencephalitis.Antimicrobial agents and chemotherapy · 1997Article
- Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.Antimicrobial agents and chemotherapy · 1997Article
- L3T4(CD4)-, Lyt-2(CD8)- and Mac-1(CD11b)-phenotypic leukocytes in murine cryptococcal meningoencephalitis.Mycopathologia · 1995Article
- Biomolecular events involved in anticryptococcal resistance in the brain.Infection and immunity · 1995Article
- Anticryptococcal resistance in the mouse brain: beneficial effects of local administration of heat-inactivated yeast cells.Infection and immunity · 1994Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A murine model of intracerebral (i.c.) infection with Cryptococcus neoformans in which naive mice receiving an i.c. fungal inoculation developed a severe disease has been established. The effect was strictly dependent on the number of microorganisms injected and evolved as lethal meningoencephalitis. Murine susceptibility to i.c. infection with C. neoformans was enhanced by treatment with chloroquine and colchicine, agents known to greatly affect the host phagocytic compartment. Furthermore, the life spans of both naive and drug-treated mice were significantly augmented when opsonized fungi were injected. Therefore, phagocyte-mediated mechanisms are likely involved in local resistance to i.c. infection with C. neoformans. Further support for this conclusion was supplied by in vitro data showing that microglial cells were proficient anticryptococcal effectors, provided opsonized microorganisms were used.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.