ArticleInfection and immunity1992
Host cell actin assembly is necessary and likely to provide the propulsive force for intracellular movement of Listeria monocytogenes.
Article in Infection and immunity, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 163 citations in OpenAlex.
- A pore-forming toxin initiates ABI1 complex switching to promote bacterial cell-to-cell spread.Nature communications · 2026Article
- Egress of Listeria monocytogenes from Mesenteric Lymph Nodes Depends on Intracellular Replication and Cell-to-Cell Spread.Infection and immunity · 2023Article
- Force-velocity relation and load-sharing in the linear polymerization ratchet revisited: the effects of barrier diffusion.The European physical journal. E, Soft matter · 2022Article
- Recapitulation of molecular regulators of nuclear motion during cell migration.Cell adhesion & migration · 2019Review
- Morphological changes of plasma membrane and protein assembly during clathrin-mediated endocytosis.PLoS biology · 2018Article
- The diaphanous-related formins promote protrusion formation and cell-to-cell spread of Listeria monocytogenes.The Journal of infectious diseases · 2015Article
- Three-dimensional architecture of actin filaments in Listeria monocytogenes comet tails.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Arp2/3-mediated actin-based motility: a tail of pathogen abuse.Cell host & microbe · 2013Review
- Yogi Berra, Forrest Gump, and the discovery of Listeria actin comet tails.Molecular biology of the cell · 2012Article
- A model actin comet tail disassembling by severing.Physical biology · 2011Article
- A microscopic formulation for the actin-driven motion of listeria in curved paths.Biophysical journal · 2010Article
- Rapid actin-dependent viral motility in live cells.Biophysical journal · 2009Article
- The Key Events Dose-Response Framework: its potential for application to foodborne pathogenic microorganisms.Critical reviews in food science and nutrition · 2009Article
- Bacillus anthracis edema toxin impairs neutrophil actin-based motility.Infection and immunity · 2009Article
- Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers.The Journal of cell biology · 2008Article
- Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition.Cell host & microbe · 2008Article
- Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation.The EMBO journal · 2007Article
- Large-scale quantitative analysis of sources of variation in the actin polymerization-based movement of Listeria monocytogenes.Biophysical journal · 2005Article
- Gelsolin mediates calcium-dependent disassembly of Listeria actin tails.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Listeria monocytogenes actin-based motility varies depending on subcellular location: a kinematic probe for cytoarchitecture.Molecular biology of the cell · 2004Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Listeria monocytogenes is able to escape from the phagolysosome and grow within the host cell cytoplasm. By 3 h after initiation of infection, actin filaments begin to concentrate at one end of the bacterium. Polarization of F-actin is associated with intracellular bacterial movement, long projections of actin filaments forming directly behind the moving bacteria. New actin monomers are added to the region of the projection in proximity to the bacterium. The rate of new actin filament growth correlates closely with the speed of bacterial migration. This actin structure is anchored within the cytoplasm, serving as a fixed platform for directional expansion of the actin filament network. The actin projection progressively lengthens as the bacterium migrates. Cytochalasin blocks both elongation of the projection and bacterial movement but does not result in complete depolymerization of the bacterially induced actin structure, residual actin and alpha-actinin persisting in proximity to one end of the bacterium. Bacteria initially migrate within the cortical cytoplasm but later move to the peripheral membrane, where they form filopodiumlike structures which pivot and undulate in the extracellular medium. In the filopodia, bacteria are occasionally seen to abruptly change direction, turn 180 degrees, and move back into the medullary region of the host cell. All filopodium movement ceases once the bacterium containing the F-actin projection returns to the cortical cytoplasm. These results indicate that host cell actin polymerization is necessary for intracellular migration of listeriae and suggest that directional actin assembly may in fact generate the propulsive force for bacterial and filopodial movement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.