ReviewJournal of bioenergetics and biomembranes2003
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
Review in Journal of bioenergetics and biomembranes, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.Scientific reports · 2021Article
- Novel Pannexin-1-Coupled Signaling Cascade Involved in the Control of Endothelial Cell Function and NO-Dependent Relaxation.Oxidative medicine and cellular longevity · 2021Article
- Disrupted Calcium Signaling in Animal Models of Human Spinocerebellar Ataxia (SCA).International journal of molecular sciences · 2019Review
- Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.American journal of physiology. Gastrointestinal and liver physiology · 2018Article
- T-Type Calcium Channel: A Privileged Gate for Calcium Entry and Control of Adrenal Steroidogenesis.Frontiers in endocrinology · 2016Review
- Potassium depolarization and raised calcium induces α-synuclein aggregates.Neurotoxicity research · 2013Article
- Contributions of T-type voltage-gated calcium channels to postsynaptic calcium signaling within Purkinje neurons.Cerebellum (London, England) · 2012Review
- Calcium-dependent inhibition of T-type calcium channels by TRPV1 activation in rat sensory neurons.Pflugers Archiv : European journal of physiology · 2011Article
- Neuroprotective effects of blockers for T-type calcium channels.Molecular neurodegeneration · 2009Article
- Article
- T-type channels-secretion coupling: evidence for a fast low-threshold exocytosis.Pflugers Archiv : European journal of physiology · 2006Review
- Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm.The Journal of cell biology · 2005Article
- Low-voltage-activated ("T-Type") calcium channels in review.Journal of bioenergetics and biomembranes · 2003Review
- Model for transition from waves to synchrony in the olfactory lobe of Limax.Journal of computational neuroscienceArticle
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Although T-type calcium channel currents were observed almost 30 years ago, the genes that encode the pore-forming subunits have only been recently reported. When expressed in heterologous systems, three distinct alpha1 subunits (alpha1G (Cav3.1), alpha1H (Car3.2), and alpha1I (Cav3.3)) conduct T-type currents with insert similar but not identical electrophysiological characteristics that. Alpha 1G, alpha 1H, and alpha 1I transcripts are found throughout neural and nonneural tissues, suggesting multiple types of T-type channels (also called low voltage-activated calcium channels (LVAs)) are coexpressed by many tissues. The study of endogenous LVAs has been hampered by a lack of highly selective antagonists that differentiate between LVA subtypes. Furthermore, many pharmacological agents attenuate currents conducted by LVA and high voltage-activated calcium channels (HVAs). At least 15 classes of pharmacological agents affect T-type currents, and the therapeutic use of many of these drugs has implicated LVAs in the etiology of a variety of diseases. Comparison of the responses of recombinant and native LVAs to pharmacological agents and endogenous modulatory molecules will lead to a better understanding of LVAs in normal and diseased cells.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.