ReviewJournal of bioenergetics and biomembranes2003
Low-voltage-activated ("T-Type") calcium channels in review.
Review in Journal of bioenergetics and biomembranes, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- TASK inhibition by mild acidosis increases CaAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Breeding of CaScientific reports · 2021Article
- Effects of the Calcium Channel Blocker Otilonium Bromide on Seizure Activity in Rats With Pentylenetetrazole-Induced Convulsions.Neurochemical research · 2021Article
- The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.Scientific reports · 2021Article
- CaAmerican journal of physiology. Cell physiology · 2020Article
- Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Article
- Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro.Neuroscience bulletin · 2016Article
- Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments.Annals of the New York Academy of Sciences · 2015Review
- Early investigational drugs for hearing loss.Expert opinion on investigational drugs · 2015Review
- T-type calcium channel blockers as neuroprotective agents.Pflugers Archiv : European journal of physiology · 2014Review
- Models of calcium permeation through T-type channels.Pflugers Archiv : European journal of physiology · 2014Review
- Signal processing by T-type calcium channel interactions in the cerebellum.Frontiers in cellular neuroscience · 2013Review
- Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss.Hearing research · 2013Article
- Fe²⁺ block and permeation of CaV3.1 (α1G) T-type calcium channels: candidate mechanism for non-transferrin-mediated Fe²⁺ influx.Molecular pharmacology · 2012Article
- Retrieval of context-associated memory is dependent on the Ca(v)3.2 T-type calcium channel.PloS one · 2012Article
- Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel.Hearing research · 2011Article
- Voltage-gated divalent currents in descending vasa recta pericytes.American journal of physiology. Renal physiology · 2010Article
- T-type Ca(2+) channel modulation by otilonium bromide.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The past 5 years has witnessed an advance in our understanding of alpha1G (Cav3.1), alpha1H (Cav3.2), and alpha11 (Car3.3), the pore-forming subunits of T-type or low-voltage-activated calcium channels (LVAs). LVAs differ in their localization and molecular, biophysical, and biochemical properties, but all conduct a transient calcium current in a variety of cells. T-type currents mediate a number of physiological functions in developing and mature cells, and are implicated in neural and cardiovascular diseases. Hampered by a lack of selective antagonists, characterization of T-type channels has come from recombinant channel studies and use of pharmacological and electrophysiological methods to isolate endogenous T-type currents. The surprising heterogeneity in T-type currents likely results from differences in LVA molecular composition, temporal and spatial localization, and association with modulatory molecules. A fundamental knowledge of LVA biochemical properties, including the molecular composition of endogenous LVAs and spatial and temporal characterization of protein expression, is necessary to elucidate mechanisms for regulation of expression and function in normal and diseased cells.
Indexed as
Identifiers
15000520What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.