ArticleProceedings of the National Academy of Sciences of the United States of America2004
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts.Biomolecules · 2024Article
- Hormesis: Decoding Two Sides of the Same Coin.Pharmaceuticals (Basel, Switzerland) · 2015Review
- A bio-mimetic approach to DNA photoprotection.The Journal of investigative dermatology · 2014Article
- Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas.The Journal of investigative dermatology · 2012Article
- Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation.American journal of physiology. Endocrinology and metabolism · 2011Article
- Imiquimod-induced TLR7 signaling enhances repair of DNA damage induced by ultraviolet light in bone marrow-derived cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier.International journal of nanomedicine · 2011Article
- Novel investigational drugs for basal cell carcinoma.Expert opinion on investigational drugs · 2010Review
- Mimetics of hormetic agents: stress-resistance triggers.Dose-response : a publication of International Hormesis Society · 2010Article
- Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage.Journal of dermatological science · 2009Article
- Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice.The American journal of pathology · 2009Article
- Telomere homolog oligonucleotides induce apoptosis in malignant but not in normal lymphoid cells: mechanism and therapeutic potential.International journal of cancer · 2009Article
- Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice.The American journal of pathology · 2008Article
- Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells.Breast cancer research : BCR · 2007Article
- A role for WRN in telomere-based DNA damage responses.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
UV-induced DNA damage gives rise to mutations and skin cancer. We have previously reported that treatment of skin cells in vitro with thymidine dinucleotide (pTT) activates p53 and increases the ability of cells to repair subsequent UV-induced DNA damage by enhancing endogenous DNA repair capacity. Here we show that topical pTT pretreatment enhances the rate of DNA photoproduct removal, decreases UV-induced mutations, and reduces photocarcinogenesis in UV-irradiated hairless WT repair-proficient and Xpc(+/-) heterozygous partially repair-deficient mice, both transgenic for the lacZ/pUR288 mutation-indicator gene. These data support the existence of inducible mammalian DNA damage responses that increase DNA repair capacity after DNA damage and hence reduce the impact of future exposures to environmental carcinogens. The ability of topically applied pTT to induce protective physiologic responses that normally result from DNA damage suggests a previously undescribed means of reducing skin cancer in high-risk individuals.
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