ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 86 citations in OpenAlex.
- Altered peripheral taste function in a mouse model of inflammatory bowel disease.Scientific reports · 2023Article
- Macronutrient intake: Hormonal controls, pathological states, and methodological considerations.Appetite · 2023Review
- Genetic controls of Tas1r3-independent sucrose consumption in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Genetics of mouse behavioral and peripheral neural responses to sucrose.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Mental stress and physical activity interact with the genetic risk scores of the genetic variants related to sweetness preference in high sucrose-containing food and glucose tolerance.Food science & nutrition · 2020Article
- Allelic variation of the Tas1r3 taste receptor gene affects sweet taste responsiveness and metabolism of glucose in F1 mouse hybrids.PloS one · 2020Article
- Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Behavioral evidence that select carbohydrate stimuli activate T1R-independent receptor mechanisms.Appetite · 2018Article
- Genetics of Amino Acid Taste and Appetite.Advances in nutrition (Bethesda, Md.) · 2016Review
- Genetics of taste receptors.Current pharmaceutical design · 2014Review
- Taste dysfunction in BTBR mice due to a mutation of Itpr3, the inositol triphosphate receptor 3 gene.Physiological genomics · 2013Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.Journal of neurophysiology · 2012Article
- NaCl taste thresholds in 13 inbred mouse strains.Chemical senses · 2012Article
- Gustatory neural responses to umami stimuli in the parabrachial nucleus of C57BL/6J mice.Journal of neurophysiology · 2012Article
- Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.Journal of neurophysiology · 2011Article
- Genetics of sweet taste preferences.Flavour and fragrance journal · 2011Article
- Taste function in mice with a targeted mutation of the pkd1l3 gene.Chemical senses · 2010Article
- T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference.Physiological genomics · 2010Article
- Glutamate taste and appetite in laboratory mice: physiologic and genetic analyses.The American journal of clinical nutrition · 2009Review
- Variation in umami perception and in candidate genes for the umami receptor in mice and humans.The American journal of clinical nutrition · 2009Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that the T1R3 receptor protein encoded by the Tas1r3 gene is involved in transduction of sweet taste. To assess ligand specificity of the T1R3 receptor, we analyzed the association of Tas1r3 allelic variants with taste responses in mice. In the F2 hybrids between the C57BL/6ByJ (B6) and 129P3/J (129) inbred mouse strains, we determined genotypes of markers on chromosome 4, where Tas1r3 resides, measured consumption of taste solutions presented in two-bottle preference tests, and recorded integrated responses of the chorda tympani gustatory nerve to lingual application of taste stimuli. For intakes and preferences, significant linkages to Tas1r3 were found for the sweeteners sucrose, saccharin, and D-phenylalanine but not glycine. For chorda tympani responses, significant linkages to Tas1r3 were found for the sweeteners sucrose, saccharin, D-phenylalanine, D-tryptophan, and SC-45647 but not glycine, L-proline, L-alanine, or L-glutamine. No linkages to distal chromosome 4 were detected for behavioral or neural responses to non-sweet quinine, citric acid, HCl, NaCl, KCl, monosodium glutamate, inosine 5'-monophosphate, or ammonium glutamate. These results demonstrate that allelic variation of the Tas1r3 gene affects gustatory neural and behavioral responses to some, but not all, sweeteners. This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.