ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Ionic mechanism of long-lasting discharges of action potentials triggered by membrane hyperpolarization in the medial lateral habenula.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 45 citations in OpenAlex.
- Multiple bursting patterns in lateral habenula neurons: Experiments and computational model.The Journal of physiology · 2026Article
- Neuron-non-neuron electrical coupling networks are involved in chronic stress-induced electrophysiological changes in lateral habenular neurons.The Journal of physiology · 2025Article
- Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics.Journal of Zhejiang University. Science. B · 2024Review
- Role of the mesolimbic dopamine pathway in the antidepressant effects of ketamine.Neuropharmacology · 2023Review
- Article
- Review
- Identification of GABAergic neurons innervating the zebrafish lateral habenula.The European journal of neuroscience · 2020Article
- Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula.Scientific reports · 2020Article
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- Predominant Striatal Input to the Lateral Habenula in Macaques Comes from Striosomes.Current biology : CB · 2019Article
- Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression?Translational psychiatry · 2018Article
- A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress.Science signaling · 2018Article
- Article
- An emerging role for the lateral habenula in aggressive behavior.Pharmacology, biochemistry, and behavior · 2017Review
- Increased excitability of lateral habenula neurons in adolescent rats following cocaine self-administration.The international journal of neuropsychopharmacology · 2014Article
- Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity.The Journal of physiology · 2014Article
- Synaptic and cellular profile of neurons in the lateral habenula.Frontiers in human neuroscience · 2013Review
- Hyperactivation of the habenula as a link between depression and sleep disturbance.Frontiers in human neuroscience · 2013Review
- Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The activation of inhibitory synapses typically suppresses the generation of action potentials by hyperpolarizing the membrane of postsynaptic cells. In contrast to such conventional action of inhibitory synapses, we report here the ionic mechanism through which hyperpolarizing synapses trigger long-lasting discharges of action potentials that persist up to several tens of seconds. By using extracellular and intracellular recordings in slice preparations, we demonstrate that the activation of synaptic input from the limbic forebrain generates transient hyperpolarizing postsynaptic potentials in neurons of the medial part of the lateral habenular nucleus of the epithalamus. The synaptic hyperpolarization then sets off the coordinated activation of a distinct set of membrane ion channels and intracellular Ca2+ mobilization by internal stores. The activation of these cellular events in distinct temporal order drives a persistent depolarization of habenular cells and promotes long-lasting discharges of tonic action potentials. The cells in the medial division of the lateral habenula project to dopamine and serotonin cells in the midbrain. We suggest that these habenular cells, by generating persistent action potentials in response to a transient increase in the activity of the limbic forebrain, may contribute to the regulation of the serotonergic and dopaminergic activity in the brain.
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