ArticleBrain pathology (Zurich, Switzerland)2004
Selective expression of a subset of neuronal genes in oligodendroglioma with chromosome 1p loss.
Article in Brain pathology (Zurich, Switzerland), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Article
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- Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma.Oncology letters · 2021Article
- Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.Biochimica et biophysica acta. Gene regulatory mechanisms · 2018Article
- Non-invasive genotype prediction of chromosome 1p/19q co-deletion by development and validation of an MRI-based radiomics signature in lower-grade gliomas.Journal of neuro-oncology · 2018Article
- IDH-mutated astrocytomas with 19q-loss constitute a subgroup that confers better prognosis.Cancer science · 2018Article
- A composite network of conserved and tissue specific gene interactions reveals possible genetic interactions in glioma.PLoS computational biology · 2017Article
- Switching metal ion coordination and DNA Recognition in a Tandem CCHHC-type zinc finger peptide.Inorganic chemistry · 2013Article
- Tumor prognostic factors and the challenge of developing predictive factors.Current oncology reports · 2013Article
- MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas.Neuro-oncology · 2011Article
- Construct and Compare Gene Coexpression Networks with DAPfinder and DAPview.BMC bioinformatics · 2011Article
- Tumor profiling: development of prognostic and predictive factors to guide brain tumor treatment.Current oncology reports · 2011Review
- The use of global profiling in biomarker development for gliomas.Brain pathology (Zurich, Switzerland) · 2011Review
- Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall.Acta neuropathologica · 2010Article
- Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion.Journal of proteome research · 2010Article
- Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma.Brain pathology (Zurich, Switzerland) · 2009Article
- Using gene expression profiling to identify a prognostic molecular spectrum in gliomas.Cancer science · 2009Article
- Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile.Molecular cancer · 2008Article
- Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas.BMC bioinformatics · 2006Article
- Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas.Journal of neuro-oncology · 2006Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gliomas are classified based mainly on microscopic resemblance to their presumed glial origin such as astrocyte and oligodendrocyte. However, more objective diagnostic criteria are indispensable for the precise treatment of patients. For instance, loss of the short arm of chromosome 1 (1p) in oligodendrogliomas is recognized as an important marker for better response to chemotherapy and longer survival of the patients. To gain insight into their molecular biological background and to identify genes characterizing each subgroup, we investigated gene expression profile of the 4 glioma subsets, oligodendroglioma with and without 1p loss, diffuse astrocytoma and glioblastoma using DNA microarray. Remarkably, most of the genes showing distinctive expression in oligodendroglioma with 1p loss were also highly expressed in normal brain tissues and had neuron-related function, which included MYT1L, INA, RIMS2, SNAP97 and SNCB. Histological analysis also demonstrated that MYT1L, which were abundantly expressed in normal neuron, were certainly present in tumor cells. These results suggest that oligodendroglioma, especially with 1p loss, has more or less neuronal characteristics although oligodendroglioma is thought to originate form glial lineage cell. With further pathological studies, those neuron-related genes might be good diagnostic markers for oligodendroglioma of better prognosis as well.
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