ArticleImmunogenetics2004
Class II multiformity generated by variable MHC- DRB region configurations in the California sea lion ( Zalophus californianus).
Article in Immunogenetics, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals.Scientific reports · 2022Article
- Spatial pattern of genetic diversity and selection in the MHC class II DRB of three Neotropical bat species.BMC evolutionary biology · 2016Article
- Patterns of MHC-DRB1 polymorphism in a post-glacial island canid, the Newfoundland red fox (Vulpes vulpes deletrix), suggest balancing selection at species and population timescales.Immunogenetics · 2016Article
- Transformation of the genital epithelial tract occurs early in California sea lion development.Royal Society open science · 2016Article
- No Compensatory Relationship between the Innate and Adaptive Immune System in Wild-Living European Badgers.PloS one · 2016Article
- Common cancer in a wild animal: the California sea lion (Zalophus californianus) as an emerging model for carcinogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Extensive variation at MHC DRB in the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection.Heredity · 2013Article
- Duplication and population dynamics shape historic patterns of selection and genetic variation at the major histocompatibility complex in rodents.Ecology and evolution · 2013Article
- Natural selection on marine carnivores elaborated a diverse family of classical MHC class I genes exhibiting haplotypic gene content variation and allelic polymorphism.Immunogenetics · 2012Article
- MHC class II DQB diversity in the Japanese black bear, Ursus thibetanus japonicus.BMC evolutionary biology · 2012Article
- Independent evolution of functional MHC class II DRB genes in New World bat species.Immunogenetics · 2012Article
- MHC class II genes in the European badger (Meles meles): characterization, patterns of variation, and transcription analysis.Immunogenetics · 2012Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- Contrasting epidemic histories reveal pathogen-mediated balancing selection on class II MHC diversity in a wild songbird.PloS one · 2012Article
- MHC class II DRB diversity, selection pattern and population structure in a neotropical bat species, Noctilio albiventris.Heredity · 2011Article
- Cheetah paradigm revisited: MHC diversity in the world's largest free-ranging population.Molecular biology and evolution · 2011Article
- MHC class II DRB diversity in raccoons (Procyon lotor) reveals associations with raccoon rabies virus (Lyssavirus).Immunogenetics · 2011Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In light of the immunological importance of molecules encoded within the major histocompatibility complex ( MHC), there are numerous studies examining the variability of these genes in wildlife populations. An underlying assumption in many of these studies is that MHC diversity invariably arises from a high level of allelic variation at a single gene locus, leading to widespread descriptions of thriving species with apparently limited MHC polymorphism. Indeed, in a previous study we failed to find sequence features compatible with traditionally diverse peptide-binding functions in MHC class II ( DQA and DQB) genes in California sea lions and therefore expanded the search for polymorphism to the DRA and DRB genes. Our results show that, in contrast to Zaca-DQA, -DQB, and - DRA, Zaca-DRB has sequence features compatible with antigen binding and presentation. In fact Zaca-DRB constitutes a gene family, comprising at least seven loci, each of which exhibits limited variability, and which are present in variable configurations between individuals. This unusual mechanism for generating MHC DRB diversity is similar to that observed in the rhesus macaque, but has not been reported in any other species. The identification of a novel system of class II MHC variability in the California sea lion justifies new studies into the organizational basis of immunogenetic diversity in other marine species, and its role in infectious disease susceptibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.